ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2008
The symptoms of autonomic dysfunction in HIV-positive Africans.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Pooled it
- Direct and indirect cardiovascular and cardiometabolic sequelae of the combined anti-retroviral therapy on people living with HIV.Frontiers in physiology · 2023Review
- Association between HIV and Prevalent Hypertension and Diabetes Mellitus in South Africa: Analysis of a Nationally Representative Cross-Sectional Survey.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Linear and non-linear analysis of heart rate variability in HIV-positive patients on two different antiretroviral therapy regimens.BMC infectious diseases · 2021Article
- The Effects of Acute Aerobic Exercise on Blood Pressure, Arterial Function, and Heart Rate Variability in Men Living With HIV.Frontiers in physiology · 2021Article
- Infectious diseases causing autonomic dysfunction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Ideal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandans.AIDS research and human retroviruses · 2017Article
- Determinants of hypertension in a young adult Ugandan population in epidemiological transition-the MEPI-CVD survey.BMC public health · 2015Article
- Autonomic Function is Associated with Fitness Level in HIV-Infected Individuals.Jacobs journal of AIDS/HIV · 2015Article
- Gp120 in the pathogenesis of human immunodeficiency virus-associated pain.Annals of neurology · 2014Article
- Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.BMC infectious diseases · 2014Article
- Autonomic dysfunction is common in HIV and associated with distal symmetric polyneuropathy.Journal of neurovirology · 2013Article
- Neuromuscular complications in HIV: effects of aging.Journal of neurovirology · 2012Review
- Effects of antiretroviral therapy on autonomic function in early HIV infection: a preliminary report.International journal of medical sciences · 2012Article
- [Achalasia in a patient with HIV/HCV coinfection: detection of HCV in the esophageal tissue].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2011Article
- Article
- Neuromuscular diseases associated with HIV-1 infection.Muscle & nerve · 2009Review
- Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia.HIV clinical trialsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman immunodeficiency virus (HIV) infection is associated with autonomic neuropathy. The resultant autonomic dysfunction impairs quality of life and can have fatal consequences. Our aim was to clearly define the symptoms of autonomic dysfunction in African HIV-positive patients and determine whether these symptoms were related with (a) autonomic reflex responses (b) the degree of immunosupression.
methodsThirty-one HIV-positive treatment-naïve African patients (mean CD4 cell count 269.5 +/- 253.4/mm3) and 12 healthy controls completed a detailed questionnaire (Autonomic System Profile, Mayo Clinic, Rochester, MN) relating to specific symptoms of autonomic dysfunction. After completion of the questionnaire, subjects underwent a standard battery of autonomic reflex tests.
resultsThe autonomic symptom score was higher in the male HIV-positive patients (26.7 +/- 14.7 points) and female patients with CD4 <200/mm3 (24.7 +/- 18.0) than sex-matched controls (male controls, 9.9 +/- 6.8, P < 0.05; female controls, 8.8 +/- 10.1; P < 0.05). Six patients had scores indicative of severe autonomic dysfunction (>43.8 points). The most common autonomic symptoms were: orthostatic intolerance, secretomotor and gastrointestinal dysfunction. There was no relationship between CD4 cell counts and autonomic symptom scores. The blood pressure response to sustained handgrip was blunted, but all other cardiovascular reflex tests were within the normal range or borderline.
conclusionAfrican HIV-positive patients report symptoms of autonomic dysfunction, despite normal or borderline autonomic reflex responses.
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