ArticleMolecular and cellular biochemistry2008
External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF-kappa B pathways.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach.Brain, behavior, and immunity · 2010Trial
- Retraction Note to: External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF- B pathways.Molecular and cellular biochemistry · 2021Article
- The Calotropis Gigantea Methanolic Extract Induces Apoptosis in Human Breast Carcinoma Cells.Iranian journal of medical sciences · 2019Article
- Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation.Journal of Cancer · 2019Article
- Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations.Global advances in health and medicine · 2015Article
- The Relationship between Qi Deficiency, Cancer-related Fatigue and Quality of Life in Cancer Patients.Journal of traditional and complementary medicine · 2012Article
- External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells.Molecular and cellular biochemistry · 2012Article
- P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.BMC cancer · 2011Article
- Human Biofield Therapy and the Growth of Mouse Lung Carcinoma.Integrative cancer therapiesArticle
- A longitudinal study about the effect of practicing Yan Xin Qigong on medical care cost with medical claims data.International journal of economic researchArticle
- Human Biofield Therapy Modulates Tumor Microenvironment and Cancer Stemness in Mouse Lung Carcinoma.Integrative cancer therapiesArticle
Corrections and comments
- Retraction · 2021-04-24Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Results Not Reproducible ·
- Retracted
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term clinical observations and ongoing studies have shown antitumor effects of external Qi of Yan Xin Qigong (YXQG-EQ) that originated from traditional Chinese medicine (TCM). In order to understand the molecular mechanisms underlying the antitumor effects of YXQG-EQ, we investigate the effects of YXQG-EQ on growth and apoptosis in androgen-independent prostate cancer PC3 cells. We found that exposure to YXQG-EQ led to G2/M arrest associated with reduced cyclin B1 expression and apoptosis in PC3 cells. YXQG-EQ treatment inhibited constitutive and epidermal growth factor-induced Akt phosphorylation, basal and TNF-alpha-induced NF-kappaB activation, and downregulated anti-apoptotic Bcl-2 and Bcl-xL expression. In contrast, exposure to YXQG-EQ increased phosphorylation of Akt and Erk1/2 in human umbilical vein endothelial cells (HUVEC), and had no cytotoxic effect on either HUVEC or peripheral blood mononuclear cells (PBMC). These results indicate that YXQG-EQ has profound effects on growth and apoptosis of prostate cancer cells by targeting survival pathways including the Akt and NF-kappa B pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.