ArticleMolecular and cellular biochemistry2008
Physical properties of two types of calcium stores and SERCAs in human platelets.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Guardians of T-Cell CaCells · 2026Review
- HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.Haematologica · 2013Article
- Endoplasmic reticulum calcium pumps and cancer cell differentiation.Biomolecules · 2012Article
- The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.Cold Spring Harbor perspectives in biology · 2011Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to obtain experimental data depending on the properties of calcium stores and SERCAs, to analyse these data in terms of the models based on simulation of the cellular compartments as communicating vessels, and to relate this way the data to the above properties. The main characteristics of the stores and corresponding SERCAs have been estimated. Calcium content in the DTS is approximately 1.5 x 10(6) ions per cell, that in the acidic stores, approximately 0.64 x 10(6) ions per cell. The rate constant of background calcium leakage from the DTS is approximately 0.0033 s(-1), that from the acidic stores, approximately 0.1 s(-1). The background activity of SERCA2b is approximately 0.22 x 10(6 )s(-1) ions per cell, that of SERCA3, approximately 2.5 x 10(6 )s(-1) ions per cell. The properties of both calcium stores and the SERCAs and the characteristics found might be related to physiological or pathological state of the cells.
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