ReviewLung2008
The cough reflex in animals: relevance to human cough research.
Review in Lung, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An update and systematic review on drug therapies for the treatment of refractory chronic cough.Expert opinion on pharmacotherapy · 2018Pooled it
- Article
- The lipid language of tuberculosis:mBio · 2026Review
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Airflow Determines Natural Airborne Transmission of Tuberculosis in a Guinea Pig Model.bioRxiv : the preprint server for biology · 2025Article
- Article
- No Pain, No Gain (and No Cough)? Discrete Brainstem Nuclei Coordinate Reflexive Cough and Pain Responses.American journal of respiratory cell and molecular biology · 2025Article
- Article
- Evidence for AlphaThe Journal of pharmacology and experimental therapeutics · 2022Article
- Neural control of the lower airways: Role in cough and airway inflammatory disease.Handbook of clinical neurology · 2022Review
- Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough.Clinical pharmacology and therapeutics · 2021Review
- Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.ERJ open research · 2021Article
- Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities.Heliyon · 2020Article
- Article
- Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances.Physiological research · 2020Article
- Role of reactive oxygen species and TRP channels in the cough reflex.Cell calcium · 2016Review
- Evolution of lung breathing from a lungless primitive vertebrate.Respiratory physiology & neurobiology · 2016Article
- Review
- Resuscitation and auto resuscitation by airway reflexes in animals.Cough (London, England) · 2013Article
- Perspective on the human cough reflex.Cough (London, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
All mammalian species studied cough or display some similar respiratory reflex upon aerosol challenge with tussigenic stimuli such as citric acid or capsaicin. Animals cough to the same stimuli that evoke coughing in humans, and therapeutic agents that display antitussive effects in human studies also prevent coughing in animals. The many invasive procedures and complementary in vitro studies possible in animals but not readily reproduced in human subjects, along with the proven predictive value of cough studies in animals, provide the rationale for animal modeling of human cough. The advantages and disadvantages of studying cough in animals are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.