ArticleJournal of muscle research and cell motility2007
A mathematical model of fatigue in skeletal muscle force contraction.
Article in Journal of muscle research and cell motility, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Interplay between store-operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise.The Journal of physiology · 2026Article
- Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy.PLoS computational biology · 2026Article
- Recommendations of the Polish Zebrafish Society on the use of the zebrafish (Acta biochimica Polonica · 2026Review
- The effects of hip abductor fatigue on gait instability in older adults.Journal of neurophysiology · 2025Article
- JiSuJi, a virtual muscle for small animal simulations, accurately predicts force from naturalistic spike trains.bioRxiv : the preprint server for biology · 2025Article
- Constitutive Models for Active Skeletal Muscle: Review, Comparison, and Application in a Novel Continuum Shoulder Model.International journal for numerical methods in biomedical engineering · 2025Review
- Multi-scale modeling and simulation of skeletal muscles with different fatigue degrees based on microphysiology.Scientific reports · 2025Article
- A chemo-mechanical constitutive model for muscle activation in bat wing skins.Journal of the Royal Society, Interface · 2024Article
- Motoneuron-driven computational muscle modelling with motor unit resolution and subject-specific musculoskeletal anatomy.PLoS computational biology · 2023Article
- Linking cortex and contraction-Integrating models along the corticomuscular pathway.Frontiers in physiology · 2023Article
- Exhaustion of Skeletal Muscle Fibers Within Seconds: Incorporating Phosphate Kinetics Into a Hill-Type Model.Frontiers in physiology · 2020Article
- Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model.Frontiers in physiology · 2019Article
- Biological Relativity Requires Circular Causality but Not Symmetry of Causation: So, Where, What and When Are the Boundaries?Frontiers in physiology · 2019Review
- Model-based analysis of fatigued human knee extensors : Effects of isometrically induced fatigue on Hill-type model parameters and ballistic contractions.European journal of applied physiology · 2018Article
- Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems.Frontiers in physiology · 2018Article
- A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation.PLoS computational biology · 2017Article
- Study of the union method of microelectrode array and AFM for the recording of electromechanical activities in living cardiomyocytes.European biophysics journal : EBJ · 2017Article
- Mechanisms of in vivo muscle fatigue in humans: investigating age-related fatigue resistance with a computational model.The Journal of physiology · 2016Article
- The Role of Parvalbumin, Sarcoplasmatic Reticulum Calcium Pump Rate, Rates of Cross-Bridge Dynamics, and Ryanodine Receptor Calcium Current on Peripheral Muscle Fatigue: A Simulation Study.Computational and mathematical methods in medicine · 2016Article
- Predicting electromyographic signals under realistic conditions using a multiscale chemo-electro-mechanical finite element model.Interface focus · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway. In this paper we construct a mathematical model of the skeletal muscle excitation-contraction pathway based on the cellular biochemical events that link excitation to contraction. The model includes descriptions of membrane voltage, calcium cycling and crossbridge dynamics and was parameterised and validated using the response characteristics of mouse skeletal muscle to a range of electrical stimuli. This model was used to uncover the complexities of skeletal muscle fatigue. We also parameterised our model to describe force kinetics in fast and slow twitch fibre types, which have a number of biochemical and biophysical differences. How these differences interact to generate different force/fatigue responses in fast- and slow- twitch fibres is not well understood and we used our modelling approach to bring new insights to this relationship.
Indexed as
Identifiers
18080210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.