ArticleDigestive diseases and sciences2008
Liver transplantation in the setting of hepatocellular carcinoma and portal vein thrombosis: a challenging dilemma?
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Transplant and non-transplant HCC patients at a single institution.Hepatology forum · 2024Article
- MRI in differentiating malignant versus benign portal vein thrombosis in patients with hepatocellular carcinoma: Value of post contrast imaging with subtraction.European journal of radiology · 2019Article
- Distinguishing Tumor From Bland Portal Vein Thrombus in Liver Transplant Candidates With Hepatocellular Carcinoma: the A-VENA Criteria.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2019Article
- Living Donor Liver Transplantation for Hepatocellular Carcinoma with Bile Duct Tumor Thrombi.Journal of gastrointestinal cancer · 2018Article
- Hepatobiliary Quiz (Answers)-15 (2015).Journal of clinical and experimental hepatology · 2015Article
- Spontaneous bleeding or thrombosis in cirrhosis: What should be feared the most?World journal of hepatology · 2015Article
- The Presence of Portal Vein Thrombosis Alters the Classic Enhancement Associated with Diagnosis of Hepatocellular Carcinoma.Digestive diseases and sciences · 2015Article
- Portal vein thrombosis.Journal of clinical and experimental hepatology · 2015Review
- An aggressive approach leads to improved survival in hepatocellular carcinoma patients with portal vein tumor thrombus.Journal of cancer research and clinical oncology · 2011Article
- Diffusion-Weighted MRI of Malignant versus Benign Portal Vein Thrombosis.Korean journal of radiologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPortal vein thrombosis (PVT) represents a potentially unfavorable prognostic factor in liver transplantation (LT) for hepatocellular carcinoma (HCC). However, it is frequently difficult to establish preoperatively whether the thrombus is associated with tumor invasion or with stagnant flow. The purpose of this study was to further address this controversial issue. PATIENTS AND
methodsWe evaluated 12 consecutive patients who underwent liver transplantation for HCC in the setting of PVT.
resultsThe origin of PVT in HCC patients could be accurately evaluated in 58% of the patients. Forty-two percent of patients had no evident portal vein invasion and only 17% of cases had tumor thrombi. One-third of patients experienced tumor recurrence within the first posttransplant year, and one-third of patients became long-term survivors (median survival of 36 months) with no evidence of tumor recurrence. One-year survival was 92%. Nine patients are currently alive after a median follow-up period of 25 months.
conclusionsPVT in the setting of HCC is characterized by poor patient outcome. However, a respectable number of instances are not accurately evaluated preoperatively, making the decision to exclude these patients from LT sometimes a challenging dilemma.
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