ArticleEndocrine2007
Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways.
Article in Endocrine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge.Biomolecules · 2025Review
- Post-translational modifications of collagen and its related diseases in metabolic pathways.Acta pharmaceutica Sinica. B · 2025Review
- Association between new anthropometric indices and osteoporosis in Chinese postmenopausal women- retrospective study based on hospitalized patients in China.Frontiers in endocrinology · 2025Article
- Novel perspectives on leptin in osteoarthritis: Focus on aging.Genes & diseases · 2024Review
- ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Progress and Challenges of Topical Delivery Technologies Meditated Drug Therapy for Osteoarthritis.International journal of nanomedicine · 2024Review
- Adipokine Signaling Pathways in Osteoarthritis.Frontiers in bioengineering and biotechnology · 2022Review
- Emerging pharmaceutical therapeutics and delivery technologies for osteoarthritis therapy.Frontiers in pharmacology · 2022Review
- Adipokines: New Therapeutic Target for Osteoarthritis?Current rheumatology reports · 2019Review
- Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model.Regenerative therapy · 2018Article
- Roles and mechanisms of leptin in osteogenic stimulation in cervical ossification of the posterior longitudinal ligament.Journal of orthopaedic surgery and research · 2018Article
- Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats.Nutrients · 2018Article
- Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK-ERK signalling pathway in vivo and in vitro.Journal of cellular and molecular medicine · 2018Article
- Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPK-ERK1/2 signaling pathway.Oncotarget · 2016Article
- Strategies to minimize hypertrophy in cartilage engineering and regeneration.Genes & diseases · 2015Article
- Nutritionally-induced catch-up growth.Nutrients · 2015Review
- Upregulation of Bone Morphogenetic Protein-2 Synthesis and Consequent Collagen II Expression in Leptin-stimulated Human Chondrocytes.PloS one · 2015Article
- Adipokines: Biomarkers for osteoarthritis?World journal of orthopedics · 2014Review
- Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.Endocrine reviews · 2013Review
- Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes.PPAR research · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic cell-line, a model for endochondral ossification, were analyzed. For this purpose, real-time PCR, Western blots and immunofluorescence techniques were used. It was found that leptin increased phosphorylation of ERK1/2, p38, and STAT3 in a time- and dose-dependent manner. Specific inhibition of STAT3 or ERK1/2, but not of P38, blocked the stimulatory effect of leptin on type X collagen mRNA levels. Moreover, leptin induced the translocation of ERK1/2 into the nucleus, as well as c-fos expression, indicating full activation of this cascade. Leptin-induced JNK phosphorylation was not observed, although leptin significantly and rapidly increased JNK protein levels and c-jun mRNA levels. In addition, ERK5 was identified in these cells, but there was no apparent effect of leptin on either its phosphorylation or protein level. The study indicates that the effects of leptin on growth-plate chondrocytes are specifically mediated through ERK1/2 and STAT3, while P38 is not essential for leptin-induced type X collagen expression. This is the first demonstration that these pathways are involved in leptin-induced growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.