ArticleThe Journal of investigative dermatology2008
Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis.
Article in The Journal of investigative dermatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Cutaneous T cell immunity.Nature immunology · 2025Review
- MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.Frontiers in immunology · 2023Article
- Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis.The Journal of allergy and clinical immunology · 2022Article
- Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases.Frontiers in immunology · 2022Review
- Raman spectroscopy enables phenotyping and assessment of nutrition values of plants: a review.Plant methods · 2021Review
- Contact dermatitis.Nature reviews. Disease primers · 2021Review
- Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.The Yale journal of biology and medicine · 2020Review
- Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.Cell reports. Medicine · 2020Article
- Review
- Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.Journal of neuroinflammation · 2020Article
- Confirmatory non-invasive and non-destructive identification of poison ivy using a hand-held Raman spectrometer.RSC advances · 2020Article
- Raman-Based Diagnostics of Biotic and Abiotic Stresses in Plants. A Review.Frontiers in plant science · 2020Review
- Innate Lymphocytes in Psoriasis.Frontiers in immunology · 2020Review
- The role of invariant T cells in inflammation of the skin and airways.Seminars in immunopathology · 2019Review
- Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica.Molecules (Basel, Switzerland) · 2018Article
- Skin Immunity.Archivum immunologiae et therapiae experimentalis · 2018Review
- Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.PloS one · 2018Article
- Therapeutic application of T regulatory cells in composite tissue allotransplantation.Journal of translational medicine · 2017Review
- Contact sensitizers trigger human CD1-autoreactive T-cell responses.European journal of immunology · 2017Article
- The EVER genes - the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients.Postepy dermatologii i alergologii · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The purpose of this study is to identify invariant natural killer T cells (NKT cells) in cellular infiltrate of human allergic contact dermatitis (ACD) skin challenge sites. Skin biopsy specimens were taken from positive patch test reactions from 10 different patients (9 different allergens) and studied by immunochemistry, real-time PCR, nested PCR, and in situ hybridization to identify NKT cells and the cytokines associated with this cell type. Invariant NKT cells were identified in all the 10 skin biopsy specimens studied, ranging from 1.72 to 33% of the cellular infiltrate. These NKT cells were activated in all cases, as they expressed cytokine transcripts for IFN-gamma and IL-4. Invariant NKT cells are present in ACD, regardless of the allergen that triggers the reaction, and are in an activated state. We conclude that innate immunity plays a role in late phases of type IV hypersensitivity reactions and may be responding to self-lipids released during allergic inflammation. These data complement the previous work by other investigators that suggest that NKT cells are important in the early cellular response during primary immune responses to allergens. Herein, it is demonstrated that NKT cells are constantly present during the late elicitation phase of human type IV hypersensitivity reactions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.