ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Four pleiotropic loci associated with fat mass and lean mass.International journal of obesity (2005) · 2020Pooled it
- Trial
- Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial.The Journal of clinical endocrinology and metabolism · 2012Trial
- Regional differences in subcutaneous adipose tissue gene expression.Obesity (Silver Spring, Md.) · 2012Trial
- The nature of sex differences in catecholamine-induced lipolysis in subcutaneous fat cells.iScience · 2025Article
- Impact of Abdominal and Thigh Intermuscular Adipose Tissue on Glucose and Cardiometabolic Risk in Adults With Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- The Impact of Exercise Training Plus Dietary Interventions on Ectopic Fat in Population with Overweight/Obesity with and without Chronic Disease: A Systematic Review, Meta-analysis, and Metaregression of Randomized Clinical Trials.Current developments in nutrition · 2025Review
- Handlebar Width Choices Must Be Considered for Female Cyclists.Journal of functional morphology and kinesiology · 2025Article
- Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature.Current obesity reports · 2024Review
- Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders.Frontiers in nutrition · 2024Review
- Non-alcoholic fatty liver disease in women - Current knowledge and emerging concepts.JHEP reports : innovation in hepatology · 2023Review
- Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women.Obesity (Silver Spring, Md.) · 2023Article
- Growth and adiposity in newborns study (GAINS): The influence of prenatal DHA supplementation protocol.Contemporary clinical trials · 2023Article
- Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus.World journal of experimental medicine · 2023Review
- Intermuscular adipose tissue in metabolic disease.Nature reviews. Endocrinology · 2023Review
- Gender similarities and differences in skeletal muscle and body composition: an MRI study of recreational cyclists.BMJ open sport & exercise medicine · 2023Article
- Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity.Alzheimer's research & therapy · 2022Article
- 3T-MRI-based age, sex and site-specific markers of musculoskeletal health in healthy children and young adults.Endocrine connections · 2022Article
- A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women.Journal of clinical medicine · 2022Article
- Changes in Adiposity and Cerebrospinal Fluid Biomarkers Following a Modified Mediterranean Ketogenic Diet in Older Adults at Risk for Alzheimer's Disease.Frontiers in neuroscience · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Femoral-gluteal adipose tissue (AT) may be cardioprotective through fatty acids uptake. Femoral-gluteal AT has previously been defined as leg fat measured by dual energy x-ray absorptiometry (DXA); however, subcutaneous adipose tissue (SAT) and intermuscular adipose tissue (IMAT) are inseparable using DXA. This study investigated the independent relationships between femoral-gluteal SAT, femoral-gluteal IMAT, and cardiovascular disease (CVD) risk factors [fasting serum measures of glucose, total cholesterol (TC), high density lipoprotein cholesterol (HDLC), triglycerides (TG) and insulin] and whether race differences exist in femoral-gluteal AT distribution. Adult Caucasians (56 men and 104 women), African-Americans (37 men and 76 women), and Asians (11 men and 35 women) had total AT (TAT) including femoral-gluteal AT (upper leg SAT and IMAT) and visceral AT (VAT) by magnetic resonance imaging (MRI). General linear models identified the independent effects of femoral-gluteal SAT and femoral-gluteal IMAT on each risk factor after covarying for TAT, VAT, age, race, sex, and two-way interactions. Femoral-gluteal IMAT and glucose (P < 0.05) were positively associated independent of VAT. There were also significant inverse associations between femoral-gluteal SAT and insulin (P < 0.01) and TG (P < 0.05), although the addition of VAT rendered these effects nonsignificant, possibly due to collinearity. Asian women had less femoral-gluteal SAT and greater VAT than Caucasians and African-Americans (P < 0.05) and Asian and African-American men had greater femoral-gluteal IMAT than Caucasians, adjusted for age and TAT (P < 0.05 for both). Femoral-gluteal SAT and femoral-gluteal IMAT distribution varies by sex and race, and these two components have independent and opposing relationships with CVD risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.