ReviewThe Journal of physiology2008
Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites.
Review in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- Neurodevelopmental Disorders: Effect of High-Fat Diet on Synaptic Plasticity and Mitochondrial Functions.Brain sciences · 2020Review
- Target-dependent retrograde signaling mediates synaptic plasticity at the Drosophila neuromuscular junction.Developmental neurobiology · 2019Article
- Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The subthreshold-active KCommunications biology · 2019Article
- Metabotropic glutamate receptor trafficking.Molecular and cellular neurosciences · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum.Oncotarget · 2017Article
- Target-Dependent Compartmentalization of the Corelease of Glutamate and GABA from the Mossy Fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.Human molecular genetics · 2017Article
- P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies.Current neuropharmacology · 2016Review
- Synaptic proteins in the hippocampus indicative of increased neuronal activity in CA3 in schizophrenia.The American journal of psychiatry · 2015Article
- Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin.Molecular psychiatry · 2015Article
- Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells.Neuron · 2015Article
- Presynaptic long-term depression mediated by Gi/o-coupled receptors.Trends in neurosciences · 2014Review
- Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.The Journal of biological chemistry · 2014Article
- Presynaptic long-term plasticity.Frontiers in synaptic neuroscience · 2013Review
- Psychosis is emerging as a learning and memory disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Neuroscience. Decoding the neuronal Tower of Babel.Science (New York, N.Y.) · 2012Article
- Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling.Schizophrenia bulletin · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Individual axons of central neurons innervate a large number of distinct postsynaptic targets belonging to divergent functional categories such as glutamatergic principal cells and inhibitory interneurons. While each bouton along a common axon should experience the same activity pattern in response to action potential firing within the parent presynaptic neuron, accumulating evidence suggests that neighbouring boutons contacting functionally distinct postsynaptic targets regulate their release properties independently, despite being separated by only a few microns. This target-cell-specific autonomy of presynaptic function can greatly expand the computational prowess of central axons to allow for precise coordination of large neuronal ensembles within a given circuit. An excellent example of target-cell-specific presynaptic mechanisms occurs in the CA3 hippocampus where mossy fibre (MF) axons of dentate gyrus granule cells target both principal cells and local circuit inhibitory interneurons via both anatomically and functionally specialized terminals. Of particular interest, mechanisms of both short- and long-term plasticity remain autonomous at these divergent release sites due to an anatomical and biochemical segregation of discrete molecular signalling cascades. Here we review roughly a decades worth of research on the MF-CA3 pathway to showcase the target-cell dependence of presynaptically expressed NMDA receptor-independent synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.