ArticleMetabolism: clinical and experimental2008
Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome.
Article in Metabolism: clinical and experimental, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Metabolic syndrome, hypertension, and hyperlipidemia in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis.Fertility and sterility · 2018Pooled it
- Polyendocrine metabolic ovarian syndrome in pregnancy: pathophysiology and outcomes.Nature reviews. Endocrinology · 2026Review
- Male polycystic ovarian syndrome phenotype: a meta-analysis of endocrine-metabolic dysregulation in fathers and brothers of PCOS-affected women.Basic and clinical andrology · 2025Article
- Adverse Cardiometabolic Outcomes in Men With Sisters With Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2025Article
- Polycystic ovary syndrome.Nature reviews. Disease primers · 2024Review
- Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome.Cell reports. Medicine · 2023Article
- Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance.International journal of molecular sciences · 2023Review
- Update on Animal Models of Polycystic Ovary Syndrome.Endocrinology · 2022Article
- Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk.Obesity (Silver Spring, Md.) · 2020Article
- Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity.The Journal of clinical endocrinology and metabolism · 2016Article
- Article
- Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome.Human reproduction (Oxford, England) · 2014Article
- Persistent apparent pancreatic β-cell defects in premenarchal PCOS relatives.The Journal of clinical endocrinology and metabolism · 2014Article
- Parent-of-origin effects on glucose homeostasis in polycystic ovary syndrome.The Journal of clinical endocrinology and metabolism · 2014Article
- Prevalence of metabolic syndrome in the family members of women with polycystic ovary syndrome from North India.Indian journal of endocrinology and metabolism · 2014Article
- The inflammatory gene pathway is not a major contributor to polycystic ovary snydrome.The Journal of clinical endocrinology and metabolism · 2014Article
- Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.The Journal of clinical endocrinology and metabolism · 2013Article
- Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.Endocrine reviews · 2012Review
- Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome.Endocrine · 2012Review
- Altered glucose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome.International journal of pediatric endocrinology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Hyperandrogenemia and insulin resistance are heritable traits in sisters of women with polycystic ovary syndrome (PCOS). Hyperandrogenemia also appears to be the male reproductive phenotype; however, it is less clear whether male relatives are at risk for the metabolic disorders associated with PCOS. In this study, we tested the hypothesis that brothers of women with PCOS have defects in insulin action and/or secretion. Twenty-three non-Hispanic white brothers of women with PCOS and 23 non-Hispanic white control men of comparable age matched for body mass index underwent a modified frequently sampled intravenous glucose tolerance test. Parameters of insulin sensitivity and secretion were determined using minimal-model Bergman protocol. Disposition index was significantly decreased (2540 [1080, 3172] vs 2901 [2096, 4487], P = .009) independent of a family history of diabetes mellitus, and glucose effectiveness was significantly increased (2.4 [1.9, 2.7] vs 2.0 [1.8, 2.2], P = .02) in brothers compared with control men. We conclude that brothers of women with PCOS have evidence for pancreatic beta-cell dysfunction and may be at increased risk for type 2 diabetes mellitus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.