ArticleClinical biochemistry2008
Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
Article in Clinical biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Population Admixture andJournal of cardiovascular development and disease · 2026Article
- Association between theSaudi journal of biological sciences · 2021Article
- Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.Frontiers in cardiovascular medicine · 2021Review
- Genes Potentially Associated with Familial Hypercholesterolemia.Biomolecules · 2019Review
- Multiple rare and common variants in APOB gene locus associated with oxidatively modified low-density lipoprotein levels.PloS one · 2019Article
- Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes.Molecular genetics and genomics : MGG · 2018Article
- Prediction of cholesterol ratios within a Korean population.Royal Society open science · 2018Article
- Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.Lipids in health and disease · 2017Review
- Prevalence and determinants of hyperlipidemia in moderate altitude areas of the Yunnan-Kweichow plateau in Southwestern China.High altitude medicine & biology · 2012Article
- Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.European journal of epidemiology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. DESIGN AND
methodsA total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC).
resultsWe identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively.
conclusionsThe cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.
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