ArticleJournal of virology2008
A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- The Roles of Type I Interferon in Bacterial Infection.Cell host & microbe · 2016Review
- Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system.Cytokine & growth factor reviews · 2014Review
- Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages.Virology · 2013Article
- Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF).The Journal of biological chemistry · 2011Article
- Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.Journal of virology · 2010Article
- Kaposi's sarcoma-associated herpesvirus and innate immunity.Future virology · 2010Article
- Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.Journal of virology · 2010Article
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.Nature immunology · 2009Article
- Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus.Journal of virology · 2009Article
- The M10 locus of murine gammaherpesvirus 68 contributes to both the lytic and the latent phases of infection.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.