ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Balanced excitatory and inhibitory inputs to cortical neurons decouple firing irregularity from rate modulations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed.
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state.Neuron · 2026Article
- A novel image-based neuronal network model framework for understanding visual multistability and neurological disorders.Frontiers in computational neuroscience · 2026Article
- Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low-voltage-fast onset seizures in Dravet syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Logarithmically scaled, gamma distributed neuronal spiking.The Journal of physiology · 2023Review
- New insights into binocular rivalry from the reconstruction of evolving percepts using model network dynamics.Frontiers in computational neuroscience · 2023Article
- Stimulus presentation can enhance spiking irregularity across subcortical and cortical regions.PLoS computational biology · 2022Article
- Functional Implications of Dale's Law in Balanced Neuronal Network Dynamics and Decision Making.Frontiers in neuroscience · 2022Article
- The impact of spike-frequency adaptation on balanced network dynamics.Cognitive neurodynamics · 2019Article
- Compressive Sensing Inference of Neuronal Network Connectivity in Balanced Neuronal Dynamics.Frontiers in neuroscience · 2019Article
- Balanced Active Core in Heterogeneous Neuronal Networks.Frontiers in computational neuroscience · 2018Article
- The Dynamics of Balanced Spiking Neuronal Networks Under Poisson Drive Is Not Chaotic.Frontiers in computational neuroscience · 2018Article
- Photoelectrochemical immunoassay for human interleukin 6 based on the use of perovskite-type LaFeOMikrochimica acta · 2017Article
- Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.PloS one · 2015Article
- Estimation of the synaptic input firing rates and characterization of the stimulation effects in an auditory neuron.Frontiers in computational neuroscience · 2015Article
- Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Analytical approximations of the firing rate of an adaptive exponential integrate-and-fire neuron in the presence of synaptic noise.Frontiers in computational neuroscience · 2014Article
- On how correlations between excitatory and inhibitory synaptic inputs maximize the information rate of neuronal firing.Frontiers in computational neuroscience · 2014Article
- Neuronal variability of MSTd neurons changes differentially with eye movement and visually related variables.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
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4 authors.
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Abstract
In vivo cortical neurons are known to exhibit highly irregular spike patterns. Because the intervals between successive spikes fluctuate greatly, irregular neuronal firing makes it difficult to estimate instantaneous firing rates accurately. If, however, the irregularity of spike timing is decoupled from rate modulations, the estimate of firing rate can be improved. Here, we introduce a novel coding scheme to make the firing irregularity orthogonal to the firing rate in information representation. The scheme is valid if an interspike interval distribution can be well fitted by the gamma distribution and the firing irregularity is constant over time. We investigated in a computational model whether fluctuating external inputs may generate gamma process-like spike outputs, and whether the two quantities are actually decoupled. Whole-cell patch-clamp recordings of cortical neurons were performed to confirm the predictions of the model. The output spikes were well fitted by the gamma distribution. The firing irregularity remained approximately constant regardless of the firing rate when we injected a balanced input, in which excitatory and inhibitory synapses are activated concurrently while keeping their conductance ratio fixed. The degree of irregular firing depended on the effective reversal potential set by the balance between excitation and inhibition. In contrast, when we modulated conductances out of balance, the irregularity varied with the firing rate. These results indicate that the balanced input may improve the efficiency of neural coding by clamping the firing irregularity of cortical neurons. We demonstrate how this novel coding scheme facilitates stimulus decoding.
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