ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Vestibular signals in primate thalamus: properties and origins.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities.Cerebellum (London, England) · 2013Trial
- A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T.Psychopharmacology · 2009Trial
- Distributed burst firing mediates optimized cortical encoding of natural self-motion.Science advances · 2026Article
- Vestibular nucleus-thalamus-cortex pathway abnormalities persist in patients with chronic unilateral vestibulopathy after the establishment of vestibular static compensation.Quantitative imaging in medicine and surgery · 2026Article
- Cortical vestibular-visual interactions and cross-modal plasticity-adaptive neural processes for stable perception.Frontiers in neural circuits · 2026Review
- Trigeminal Nerve and Vestibular System: Update on Pathophysiological and Clinical Links.Audiology research · 2025Review
- A wide-ranging review of galvanic vestibular stimulation: from its genesis to basic science and clinical applications.Experimental brain research · 2025Review
- Reference Frames for Encoding of Translation and Tilt in the Caudal Cerebellar Vermis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease?Cerebellum (London, England) · 2024Article
- Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review).International journal of molecular medicine · 2024Review
- Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.Annual review of neuroscience · 2023Review
- Vestibulo-spatial navigation: pathways and sense of direction.Journal of neurophysiology · 2023Article
- Neural substrates of perception in the vestibular thalamus during natural self-motion: A review.Current research in neurobiology · 2023Review
- Utricular dysfunction in patients with orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Sensory adaptation mediates efficient and unambiguous encoding of natural stimuli by vestibular thalamocortical pathways.Nature communications · 2022Article
- Longitudinal [Scientific reports · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- The neural basis for violations of Weber's law in self-motion perception.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Frequency-Specific Effects of Galvanic Vestibular Stimulation on Response-Time Performance in Parkinson's Disease.Frontiers in neurology · 2021Article
- Neural variability determines coding strategies for natural self-motion in macaque monkeys.eLife · 2020Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Vestibular activation is found in diverse cortical areas. To characterize the pathways and types of signals supplied to cortex, we recorded responses to rotational and/or translational stimuli in the macaque thalamus. Few cells responded to rotation alone, with most showing convergence between semicircular canal and otolith signals. During sinusoidal rotation, thalamic responses lead head velocity by approximately 30 degrees on average at frequencies between 0.01-4 Hz. During translation, neurons encoded combinations of linear acceleration and velocity. In general, thalamic responses were similar to those recorded in the vestibular and cerebellar nuclei using identical testing paradigms, but differed from those of vestibular afferents. Thalamic responses represented a biased continuum: most cells more strongly encoded translation and fewer cells modulated primarily in response to net gravitoinertial acceleration. Responsive neurons were scattered within a large area that included regions of the ventral posterior and ventral lateral nuclei, and so were not restricted to the known vestibular nuclei projection zones. To determine the origins of these responses, a retrograde tracer was injected into a dorsolateral thalamic site where rotation/translation-sensitive cells were encountered. This injection labeled neurons in the rostral contralateral anterior interposed and fastigial nuclei, but did not label cells within the vestibular nuclei. Examination of thalamic terminations after tracer injections into the cerebellar and vestibular nuclei indicated that most vestibular responsive units fall within the thalamic terminal zones of these nuclei. Thus, vestibular signals, which are supplied to the thalamus from both vestibular and cerebellar nuclei, are positioned for distribution to widespread cortical areas.
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