ArticleClinical and vaccine immunology : CVI2008
Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 85 citations in OpenAlex.
- Blinded trial of multiplex serodiagnostic test in India for diverse forms of active tuberculosis.Microbiology spectrum · 2026Article
- Matrix Metalloproteinases 7 and 10 Are Prognostic Biomarkers for Systemic Cardiovascular Risk in Individuals with Peripheral Artery Disease.Biomolecules · 2025Article
- Antibodies as clinical tools for tuberculosis.Frontiers in immunology · 2023Review
- Differential levels of anti-Frontiers in medicine · 2023Article
- The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool.Frontiers in microbiology · 2022Review
- Searching for a technology-driven acute rheumatic fever test: the START study protocol.BMJ open · 2021Article
- Automated machine learning for endemic active tuberculosis prediction from multiplex serological data.Scientific reports · 2021Article
- Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting.PloS one · 2021Article
- Immunological Aspects of Diagnosis and Management of Childhood Tuberculosis.Infection and drug resistance · 2021Review
- Evaluation of multi-antigen serological screening for active tuberculosis among people living with HIV.PloS one · 2020Article
- A Bead-Based Flow Cytometric Assay for Monitoring Yersinia pestis Exposure in Wildlife.Journal of clinical microbiology · 2018Article
- Article
- Evaluation of antibody responses to panels of M. tuberculosis antigens as a screening tool for active tuberculosis in Uganda.PloS one · 2017Article
- Serological diagnosis of pulmonary Mycobacterium tuberculosis infection by LIPS using a multiple antigen mixture.BMC microbiology · 2015Article
- Monkey models of tuberculosis: lessons learned.Infection and immunity · 2015Review
- Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay.PLoS neglected tropical diseases · 2015Article
- Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity.PloS one · 2014Article
- Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.PLoS neglected tropical diseases · 2014Article
- Micropatterned photodegradable hydrogels for the sorting of microbeads and cells.Angewandte Chemie (International ed. in English) · 2013Article
- Mycobacterium smegmatis in skin biopsy specimens from patients with suppurative granulomatous inflammation.Journal of clinical microbiology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Tuberculosis (TB) is a serious global disease. The fatality rate attributed to TB is among the highest of infectious diseases, with approximately 2 million deaths occurring per year worldwide. Identification of individuals infected with Mycobacterium tuberculosis and screening of their immediate contacts is crucial for controlling the spread of TB. Current methods for detection of M. tuberculosis infection are not efficient, in particular, for testing large numbers of samples. We report a novel and efficient multiplex microbead immunoassay (MMIA), based on Luminex technology, for profiling antibodies to M. tuberculosis. Microbead sets identifiable by unique fluorescence were individually coated with each of several M. tuberculosis antigens and tested in multiplex format for antibody detection in the experimental nonhuman primate model of TB. Certain M. tuberculosis antigens, e.g., ESAT-6, CFP-10, and HspX, were included to enhance the specificity of the MMIA, because these antigens are absent in nontuberculous mycobacteria and the vaccine strain Mycobacterium bovis bacillus Calmette-Guérin. The MMIA enabled simultaneous detection of multiple M. tuberculosis plasma antibodies in several cohorts of macaques representing different stages of infection and/or disease. Antibody profiles were defined in early and latent/chronic infection. These proof-of-concept findings demonstrate the potential clinical use of the MMIA. In addition, the MMIA serodetection system has a potential for mining M. tuberculosis open reading frames (about 4,000) to discover novel target proteins for the development of more-comprehensive TB serodiagnostic tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.