ArticleProceedings of the National Academy of Sciences of the United States of America2007
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- A history of cesarean section and future maternal long-term risk for neoplasms: a population-based cohort study.Archives of gynecology and obstetrics · 2023Article
- Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.Scientific reports · 2020Article
- Disease progression in relation to pre-onset parity among women with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2020Article
- Individuals at risk of seropositive rheumatoid arthritis: the evolving story.Journal of internal medicine · 2019Review
- Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.Frontiers in immunology · 2019Review
- Increased risk of rheumatoid arthritis among mothers with children who carryAnnals of the rheumatic diseases · 2017Article
- Juvenile idiopathic arthritis in relation to perinatal and maternal characteristics: a case control study.Pediatric rheumatology online journal · 2017Article
- Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The role of common protective alleles HLA-DRB1*13 among systemic autoimmune diseases.Genes and immunity · 2017Review
- Rheumatoid Arthritis: The Stride from Research to Clinical Practice.International journal of molecular sciences · 2016Review
- Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.Journal of human genetics · 2015Review
- Review
- Proteomic analysis of synovial fluid: insight into the pathogenesis of knee osteoarthritis.International orthopaedics · 2013Article
- Article
- On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin study.PloS one · 2013Article
- The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.Frontiers in neuroscience · 2013Article
- The otherness of self: microchimerism in health and disease.Trends in immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e., HLA-DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304) are associated with protection from RA. It has been proposed that not only inherited but also noninherited HLA-antigens from the mother (NIMA) can influence RA-susceptibility. Up to now, no protective NIMAs were described. Here, we studied whether DERAA-containing HLA-DRB1-alleles as NIMA are associated with a protective effect. One hundred seventy-nine families were studied, 88 from the Netherlands and 91 from the United Kingdom. The frequency of DERAA-containing HLA-DRB1-alleles of the Dutch mothers (16.1%), but not of the fathers (26.2%), was lower compared with the general Dutch population (29.3%; P = 0.02). This was replicated in the English set of patients and controls (P = 0.01). Further, of all families, 45 contained at least one DERAA-negative child with RA and at least one DERAA-positive parent. The odds for the DERAA-negative RA patients of having a DERAA-positive mother was significantly lower compared with having a DERAA-positive father (OR 0.25; P = 0.003). These data show a protective NIMA-effect in a human autoimmune disease and indicate that a DERAA-positive mother can transfer protection against RA to her DERAA-negative child.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.