ArticleProceedings of the National Academy of Sciences of the United States of America2007
Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Contribution of integrin adhesion to cytokinetic abscission and genomic integrity.Frontiers in cell and developmental biology · 2022Review
- Septin and Ras regulate cytokinetic abscission in detached cells.Cell division · 2019Article
- Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis.Nature cell biology · 2018Article
- Tension-induced cytokinetic abscission in human fibroblasts.Oncotarget · 2018Article
- A novel mode of cytokinesis without cell-substratum adhesion.Scientific reports · 2017Article
- EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells.eLife · 2016Article
- Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody.Oncotarget · 2016Article
- Article
- Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication.Cell cycle (Georgetown, Tex.) · 2016Article
- Matrix compliance and the regulation of cytokinesis.Biology open · 2015Article
- Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.Cell cycle (Georgetown, Tex.) · 2015Article
- Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression.Nucleic acids research · 2014Article
- Integrins promote cytokinesis through the RSK signaling axis.Journal of cell science · 2014Article
- Fibronectin assembly in the crypts of cytokinesis-blocked multilobular cells promotes anchorage-independent growth.PloS one · 2013Article
- A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin.PloS one · 2013Article
- Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.Oncogene · 2012Article
- Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.The EMBO journal · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell anchorage is required for cell proliferation of untransformed cells, whereas anchorage-independent growth can be induced by oncogenes and is a hallmark of transformation. Whereas anchorage-dependent control of the progression of the G(1) phase of the cell cycle has been extensively studied, it is less clear whether and how anchorage may control other cell cycle phases and whether oncogenes may affect such controls. Here, we found that lack of cell anchorage did not influence progression through the cell cycle S phase, G(2) phase, or most of mitosis of primary human fibroblasts. However, unanchored fibroblasts could not complete cytokinesis. The cleavage furrow and central spindle were still formed in the absence of anchorage, but cells were unable to complete ingression, causing binucleation. Importantly, V12 H-Ras-transformed fibroblasts and two cancer cell lines progressed through the entire cell cycle without anchorage, including through cytokinesis. This indicates that oncogenic signaling may contribute to anchorage-independent growth and tumorigenesis by promoting the final cleavage furrow ingression during cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.