Trial reportInternational journal of cancer2008
Birth-related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: the ESCALE study (SFCE).
Trial report in International journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Assisted Reproductive Technology and Risk of Childhood Cancer Among the Offspring of Parents With Infertility: Systematic Review and Meta-Analysis.JMIR cancer · 2025Pooled it
- Risk factors of neuroblastoma: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Maternal Medication Use and Childhood Cancer in Offspring-Systematic Review and Considerations for Researchers.American journal of epidemiology · 2021Pooled it
- Cancer risk in children and young adults born preterm: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Pooled it
- Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature.European journal of pediatrics · 2009Pooled it
- Causal links between congenital malformations, birth weight, and neuroblastoma: insights from Mendelian randomization.BMC pediatrics · 2025Article
- NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma.EMBO reports · 2023Article
- The association between birth weight and the risk of neuroblastoma: a meta-analysis of observational studies involving 4,361,141 participants.American journal of cancer research · 2023Review
- Temporal clustering of neuroblastic tumours in children and young adults from Northern England.Environmental health : a global access science source · 2015Article
- Neonatal tumours.Pediatric surgery international · 2013Review
- Cancer in children with nonchromosomal birth defects.The Journal of pediatrics · 2012Article
- Birth order and risk of childhood cancer: a pooled analysis from five US States.International journal of cancer · 2011Article
- Molecular pathogenesis of peripheral neuroblastic tumors.Oncogene · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since neuroblastoma occurs very early in children's lives, it has been hypothesized that pre- and perinatal factors may play a role in its etiology. This study investigated the role of birth characteristics, congenital malformation and maternal reproductive history in neuroblastoma. The data used were generated by the national population-based case-control study, ESCALE, conducted in France in 2003-2004. The mothers of 191 neuroblastoma cases and 1,681 controls, frequency-matched by age and gender, were interviewed by telephone, using a standardized questionnaire, on several factors including pregnancy, medical history, lifestyle, childhood medical conditions and exposures. A positive association between congenital malformation and all neuroblastoma cases was observed [Odds ratio (OR) = 2.2, 95% confidence interval (95% CI): 1.1-4.5]. Congenital malformations were highly associated to neuroblastoma in children aged less than 1 year (OR = 16.8, 95% CI: 3.1-90), while no association was observed in children aged 1 year or more (OR = 1.0, 95% CI: 0.3-2.9). A negative association with a maternal history of spontaneous abortions was also found (OR = 0.6, 95% CI: 0.4-0.9). The results strongly support the hypothesis that congenital anomalies may be associated with neuroblastoma, particularly in infant (less than 1 year of age).
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Registered trials
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