ArticleChembiochem : a European journal of chemical biology2008
Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics.
Article in Chembiochem : a European journal of chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate.Journal of medicinal chemistry · 2022Article
- Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2016Article
- Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes.Chemical communications (Cambridge, England) · 2016Review
- Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.Bioconjugate chemistry · 2016Article
- Bacterial imaging and photodynamic inactivation using zinc(II)-dipicolylamine BODIPY conjugates.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2015Article
- Evaluation of [¹¹¹In]-labeled zinc-dipicolylamine tracers for SPECT imaging of bacterial infection.Molecular imaging and biology · 2015Article
- Chemically triggered release of 5-aminolevulinic acid from liposomes.RSC advances · 2014Article
- Effect of Bridging Anions on the Structure and Stability of Phenoxide Bridged Zinc Dipicolylamine Coordination Complexes.Supramolecular chemistry · 2013Article
- Article
- Selective non-covalent triggered release from liposomes.Chemical communications (Cambridge, England) · 2012Article
- Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.European journal of inorganic chemistry · 2012Article
- Selective anion binding by a cofacial binuclear zinc complex of a Schiff-base pyrrole macrocycle.Inorganic chemistry · 2011Article
- Optical imaging of bacterial infection in living mice using deep-red fluorescent squaraine rotaxane probes.Bioconjugate chemistry · 2010Article
- Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces.Journal of the American Chemical Society · 2010Article
- Application of metal coordination chemistry to explore and manipulate cell biology.Chemical reviews · 2009Review
- Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging.Chemical communications (Cambridge, England) · 2008Article
- Optical imaging of bacterial infections.Clinical and translational imagingReview
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Authors and funding
12 authors.
Funding
Abstract
Molecular probes with zinc(II)-(2,2'-dipicolylamine) coordination complexes associate with oxyanions in aqueous solution and target biomembranes that contain anionic phospholipids. This study examines a new series of coordination complexes with 2,6-bis(zinc(II)-dipicolylamine)phenoxide as the molecular recognition unit. Two lipophilic analogues are observed to partition into the membranes of zwitterionic and anionic vesicles and induce the transport of phospholipids and hydrophilic anions (carboxyfluorescein). These lipophilic zinc complexes are moderately toxic to mammalian cells. A more hydrophilic analogue does not exhibit mammalian cell toxicity (LD(50) >50 microg mL(-1)), but it is highly active against the Gram-positive bacteria Staphylococcus aureus (MIC of 1 microg mL(-1)). Furthermore, it is active against clinically important S. aureus strains that are resistant to various antibiotics, including vancomycin and oxacillin. The antibiotic action is attributed to its ability to depolarize the bacterial cell membrane. The intense bacterial staining that was exhibited by a fluorescent conjugate suggests that this family of zinc coordination complexes can be used as molecular probes for the detection and imaging of bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.