ArticleGenes and immunity2008
Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Gene-Specific Sex Effects on Susceptibility to Infectious Diseases.Frontiers in immunology · 2021Review
- Novel Loci Controlling Parasite Load in Organs of Mice Infected WithFrontiers in immunology · 2019Article
- Gene-specific sex effects on eosinophil infiltration in leishmaniasis.Biology of sex differences · 2016Article
- A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo.PloS one · 2013Article
- Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice.Infection and immunity · 2011Article
- Genetic control of resistance to Trypanosoma brucei brucei infection in mice.PLoS neglected tropical diseases · 2011Article
- Temporal delay of peak T-cell immunity determines Chlamydia pneumoniae pulmonary disease in mice.Infection and immunity · 2008Article
- Sex differences in the genetic architecture of susceptibility to Cryptococcus neoformans pulmonary infection.Genes and immunity · 2008Article
- The resistance of BALB/cJ mice to Yersinia pestis maps to the major histocompatibility complex of chromosome 17.Infection and immunity · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
A mouse model was used to study the genetic control of differential host response to pulmonary infection with Chlamydia pneumoniae. The A/J and C57BL/6 strains show differential response to intranasal infection with respect to their ability to clear pulmonary bacterial load and the extent of lung pathology developed by 2 weeks post infection. The genetic basis of this interstrain difference was studied by whole-genome scan in an informative [A/J x C57BL/6J] F2 cross using the pulmonary microbial load as a phenotypic readout of host response. We detected a highly significant linkage (LOD score=11.5) on chromosome 17 that overlaps with the major histocompatibility (MHC) locus. This quantitative trait locus (QTL) accounts for approximately 30% of the phenotypic variance with B6 alleles conferring susceptibility and inherited in a recessive fashion. Significant linkage was also detected to chromosome 5 in female mice, while chromosome 6 showed suggestive linkage in male mice, pointing to additional complexity in the genetic control of the difference in susceptibility observed in A/J and C57BL/6J.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.