ReviewWorld journal of surgery2008
The potential role for xanthine oxidase inhibition in major intra-abdominal surgery.
Review in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Oxidative stress markers in laparoscopic versus open colectomy for cancer: a double-blind randomized study.Surgical endoscopy · 2013Trial
- Oral allopurinol to prevent hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography.World journal of gastroenterology · 2009Trial
- Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds.Archiv der Pharmazie · 2025Review
- Quantification of quercetin from red onion (Food science & nutrition · 2024Article
- Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil fromHeliyon · 2023Article
- Mediators of Regional Kidney Perfusion during Surgical Pneumo-Peritoneum Creation and the Risk of Acute Kidney Injury-A Review of Basic Physiology.Journal of clinical medicine · 2022Review
- Synthesis, Structure and Impact of 5-Aminoorotic Acid and Its Complexes with Lanthanum(III) and Gallium(III) on the Activity of Xanthine Oxidase.Molecules (Basel, Switzerland) · 2021Article
- Mori Ramulus (Chin.Ph.)-the Dried Twigs ofMolecules (Basel, Switzerland) · 2019Article
- Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia.Oxidative medicine and cellular longevity · 2018Review
- Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.Mediators of inflammation · 2016Review
- Measurement of free radicals using electron paramagnetic resonance spectroscopy during open aorto-iliac arterial reconstruction.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Macrophages mediate colon carcinoma cell adhesion in the rat liver after exposure to lipopolysaccharide.Oncoimmunology · 2012Article
- Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice.Journal of molecular neuroscience : MN · 2010Article
- Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury.Journal of molecular neuroscience : MN · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXanthine oxidase (XO) is a cytosolic metalloflavoprotein that has been implicated in the pathogenesis of a wide spectrum of diseases, and is thought to be the most important source of oxygen-free radicals and cell damage during re-oxygenation of hypoxic tissues. Clinical studies have already shown that XO inhibition is safe and effective for the treatment of gout, tumour-lysis syndrome, and to reduce complications such as post-operative arrhythmias, myocardial infarction and mortality in cardiovascular surgery. Here, we review the evidence from two decades of animal studies that have investigated the effects of XO inhibition during intra-abdominal surgery. MATERIALS AND
methodsA search of the Ovid MEDLINE database from 1950 through January 2007 was carried out using the following search terms: xanthine oxidase, allopurinol, ischemia, reperfusion, intestine, bowel, and general surgery.
resultsThe inhibition of XO has been shown to reduce oxidative stress, neutrophil priming, damage to intestinal mucosa due to ischemia reperfusion injuries, intestinal anastomotic dehiscence, bacterial translocation, adhesion formation, distant organ injury and mortality.
conclusionsDespite this evidence which very strongly suggests a likely clinically beneficial role for XO inhibition in the elective and acute operative setting, it is surprising that such an approach has not been investigated in general surgery. There is now sufficient evidence to justify dedicated studies to determine the clinical benefits, dosing and duration of XO inhibition before and after gastrointestinal surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.