ArticlePloS one2007
Revisiting estimates of CTL killing rates in vivo.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Tissue-resident memory CD4eLife · 2025Article
- Cytotoxic T Lymphocytes Control Growth of B16 Tumor Cells in Collagen-Fibrin Gels by Cytolytic and Non-Lytic Mechanisms.Viruses · 2023Article
- Mathematical modeling suggests cytotoxic T lymphocytes control growth of B16 tumor cells in collagin-fibrin gels by cytolytic and non-lytic mechanisms.bioRxiv : the preprint server for biology · 2023Article
- Evaluation of CD8 T cell killing models with computer simulations of 2-photon imaging experiments.PLoS computational biology · 2020Article
- Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data.PLoS computational biology · 2020Article
- Cancer-induced immunosuppression can enable effectiveness of immunotherapy through bistability generation: A mathematical and computational examination.Journal of theoretical biology · 2020Article
- Kill: boosting HIV-specific immune responses.Current opinion in HIV and AIDS · 2016Review
- Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive Treatment.PLoS computational biology · 2016Article
- How is the effectiveness of immune surveillance impacted by the spatial distribution of spreading infections?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities.PLoS computational biology · 2015Article
- Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models.Journal of immunology research · 2015Review
- Spatial heterogeneity and peptide availability determine CTL killing efficiency in vivo.PLoS computational biology · 2014Article
- Rates of CTL killing in persistent viral infection in vivo.PLoS computational biology · 2014Article
- Article
- Viral proteome size and CD8+ T cell epitope density are correlated: the effect of complexity on selection.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- High efficiency of antiviral CD4(+) killer T cells.PloS one · 2013Article
- The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?PLoS computational biology · 2012Article
- Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection.Proceedings. Biological sciences · 2011Article
- Virus replication strategies and the critical CTL numbers required for the control of infection.PLoS computational biology · 2011Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent experimental advances have allowed the estimation of the in vivo rates of killing of infected target cells by cytotoxic T lymphocytes (CTL). We present several refinements to a method applied previously to quantify killing of targets in the spleen using a dynamical model. We reanalyse data previously used to estimate killing rates of CTL specific for two epitopes of lymphocytic choriomeningitis virus (LCMV) in mice and show that, contrary to previous estimates the "killing rate" of effector CTL is approximately twice that of memory CTL. Further, our method allows the fits to be visualized, and reveals one potentially interesting discrepancy between fits and data. We discuss extensions to the basic CTL killing model to explain this discrepancy and propose experimental tests to distinguish between them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.