ArticlePloS one2007
Monoallelic expression of multiple genes in the CNS.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Homology-Based Interactions between Small RNAs and Their Targets Control Dominance Hierarchy of Male Determinant Alleles of Self-Incompatibility inInternational journal of molecular sciences · 2021Article
- Monoallelic expression in melanoma.Journal of translational medicine · 2019Article
- Hybrid Sterility with Meiotic Metaphase Arrest in Intersubspecific Mouse Crosses.The Journal of heredity · 2019Article
- Frequent monoallelic or skewed expression for developmental genes in CNS-derived cells and evidence for balancing selection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Characteristics of allelic gene expression in human brain cells from single-cell RNA-seq data analysis.BMC genomics · 2017Article
- Biased allelic expression in human primary fibroblast single cells.American journal of human genetics · 2015Article
- Random monoallelic expression: regulating gene expression one allele at a time.Trends in genetics : TIG · 2014Review
- Random monoallelic gene expression increases upon embryonic stem cell differentiation.Developmental cell · 2014Article
- Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.BMC medicine · 2012Review
- Exploring the role of the epigenome in multiple sclerosis: a window onto cell-specific transcriptional potential.Journal of neuroimmunology · 2012Review
- Autosomal monoallelic expression in the mouse.Genome biology · 2012Article
- Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families.PloS one · 2012Article
- Epigenetics of haematopoietic cell development.Nature reviews. Immunology · 2011Review
- Identification and resolution of artifacts in the interpretation of imprinted gene expression.Briefings in functional genomics · 2010Article
- Methods for genome-wide analysis of DNA methylation in intestinal tumors.Mutation research · 2010Review
- Dual DNA methylation patterns in the CNS reveal developmentally poised chromatin and monoallelic expression of critical genes.PloS one · 2010Article
- Trans-acting small RNA determines dominance relationships in Brassica self-incompatibility.Nature · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The inheritance pattern of a number of major genetic disorders suggests the possible involvement of genes that are expressed from one allele and silent on the other, but such genes are difficult to detect. Since DNA methylation in regulatory regions is often a mark of gene silencing, we modified existing microarray-based assays to detect both methylated and unmethylated DNA sequences in the same sample, a variation we term the MAUD assay. We probed a 65 Mb region of mouse Chr 7 for gene-associated sequences that show two distinct DNA methylation patterns in the mouse CNS. Selected genes were then tested for allele-specific expression in clonal neural stem cell lines derived from reciprocal F(1) (C57BL/6xJF1) hybrid mice. In addition, using a separate approach, we directly analyzed allele-specific expression of a group of genes interspersed within clusters of OlfR genes, since the latter are subject to allelic exclusion. Altogether, of the 500 known genes in the chromosomal region surveyed, five show monoallelic expression, four identified by the MAUD assay (Agc1, p (pink-eyed dilution), P4ha3 and Thrsp), and one by its proximity to OlfR genes (Trim12). Thrsp (thyroid hormone responsive SPOT14 homolog) is expressed in hippocampus, but the human protein homolog, S14, has also been implicated in aggressive breast cancer. Monoallelic expression of the five genes is not coordinated at a chromosome-wide level, but rather regulated at individual loci. Taken together, our results suggest that at least 1% of previously untested genes are subject to allelic exclusion, and demonstrate a dual approach to expedite their identification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.