ArticleJournal of clinical lipidology2007
Ethnic differences in low-density lipoprotein particle size in hypertensive adults.
Article in Journal of clinical lipidology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity.Human genetics · 2013Trial
- Physical Activity Is Associated With Reduced Left Ventricular Mass in Obese and Hypertensive African Americans.American journal of hypertension · 2017Article
- Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Association of serum lipids with outcomes in Hispanic hemodialysis patients of the West versus East Coasts of the United States.American journal of nephrology · 2015Article
- Managing mixed dyslipidemia in special populations.Preventive cardiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHypertensive African Americans have higher rates of coronary heart disease (CHD) than their non-Hispanic white counterparts despite having higher HDL cholesterol (HDL-C) levels and lower triglyceride levels.
objectiveThe goal of the present study was to assess whether low-density lipoprotein (LDL) particle size, a correlate of the above lipid traits and a risk factor for CHD, differs between hypertensive African Americans and whites.
methodsParticipants included 1177 hypertensive African Americans from Jackson MS (60+/-7 years, 72.4% women) and 860 hypertensive whites from Rochester MN (58+/-7 years, 56.7% women). LDL particle size was measured by polyacrylamide gradient gel electrophoresis. Within each sex, we assessed whether ethnicity was significantly associated with differences in LDL particle size after adjustment for CHD risk factors (age, total cholesterol, HDL-C, triglycerides, systolic BP, diabetes, history of smoking, body mass index), statin use, and estrogen use (in women), and "lifestyle" variables (physical activity and alcohol intake).
resultsAlthough HDL-C levels were higher and triglyceride levels lower in African Americans, LDL particle size (adjusted for CHD risk factors) was lower (P < 0.0001) in African American men and women than in their white counterparts (mean +/- SD; men, 267.6+/-5.2 A vs. 270.2+/-4.8 A; women 268.7+/-5.1 A vs. 271.3+/-5.1 A). In both sexes, African American ethnicity was associated with lower LDL particle size after adjustment for CHD risk factors, statin use and estrogen use (in women), as well as physical activity and alcohol intake.
conclusionHypertensive African American men and women have lower LDL particle size than their white counterparts despite having higher HDL-C and lower triglycerides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.