ArticleGenetics2007
Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Human genetic ancestry,eLife · 2026Article
- Feasibility and impact of haplogroup matching for mitochondrial replacement treatment.EMBO reports · 2023Article
- Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics.Trends in genetics : TIG · 2021Review
- TMPRSS6 rs855791 polymorphism and susceptibility to iron deficiency anaemia in non-dialysis chronic kidney disease patients in South Africa.International journal of molecular epidemiology and genetics · 2019Article
- Article
- Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.Genes & nutrition · 2015Article
- Inferring human population size and separation history from multiple genome sequences.Nature genetics · 2014Article
- Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences.Investigative genetics · 2014Article
- Multilocus analysis of divergence and introgression in sympatric and allopatric sibling species of the Lutzomyia longipalpis complex in Brazil.PLoS neglected tropical diseases · 2013Article
- Detecting genetic isolation in human populations: a study of European language minorities.PloS one · 2013Article
- Length distributions of identity by descent reveal fine-scale demographic history.American journal of human genetics · 2012Article
- Article
- Bayesian inference of ancient human demography from individual genome sequences.Nature genetics · 2011Article
- Demographic history and rare allele sharing among human populations.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Parallel adaptive divergence among geographically diverse human populations.PLoS genetics · 2011Article
- HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.European journal of human genetics : EJHG · 2011Article
- The society of our "out of Africa" ancestors (I): The migrant warriors that colonized the world.Communicative & integrative biology · 2011Article
- Adaptation and constraint at Toll-like receptors in primates.Molecular biology and evolution · 2010Article
- Article
- Colloquium paper: working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
12 authors.
Funding
Abstract
We estimate parameters of a general isolation-with-migration model using resequence data from mitochondrial DNA (mtDNA), the Y chromosome, and two loci on the X chromosome in samples of 25-50 individuals from each of 10 human populations. Application of a coalescent-based Markov chain Monte Carlo technique allows simultaneous inference of divergence times, rates of gene flow, as well as changes in effective population size. Results from comparisons between sub-Saharan African and Eurasian populations estimate that 1500 individuals founded the ancestral Eurasian population approximately 40 thousand years ago (KYA). Furthermore, these small Eurasian founding populations appear to have grown much more dramatically than either African or Oceanian populations. Analyses of sub-Saharan African populations provide little evidence for a history of population bottlenecks and suggest that they began diverging from one another upward of 50 KYA. We surmise that ancestral African populations had already been geographically structured prior to the founding of ancestral Eurasian populations. African populations are shown to experience low levels of mitochondrial DNA gene flow, but high levels of Y chromosome gene flow. In particular, Y chromosome gene flow appears to be asymmetric, i.e., from the Bantu-speaking population into other African populations. Conversely, mitochondrial gene flow is more extensive between non-African populations, but appears to be absent between European and Asian populations.
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