ArticleGenetics2007
Genomewide spatial correspondence between nonsynonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein.bioRxiv : the preprint server for biology · 2025Article
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- Shared evolutionary processes shape landscapes of genomic variation in the great apes.Genetics · 2024Article
- Shared evolutionary processes shape landscapes of genomic variation in the great apes.bioRxiv : the preprint server for biology · 2023Article
- Article
- Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus).Scientific reports · 2023Article
- Article
- Revisiting the notion of deleterious sweeps.Genetics · 2021Article
- Article
- Detection of hard and soft selective sweeps from Drosophila melanogaster population genomic data.PLoS genetics · 2021Article
- Estimating the genome-wide contribution of selection to temporal allele frequency change.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Exploiting selection at linked sites to infer the rate and strength of adaptation.Nature ecology & evolution · 2019Article
- Sexually dimorphic gene expression and transcriptome evolution provide mixed evidence for a fast-Z effect in Heliconius.Journal of evolutionary biology · 2019Article
- Detecting positive selection in the genome.BMC biology · 2017Review
- Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome.Molecular biology and evolution · 2017Article
- Molecular Population Genetics.Genetics · 2017Review
- Article
- On the Trail of Linked Selection.PLoS genetics · 2016Article
23 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The effect of recurrent selective sweeps is a spatially heterogeneous reduction in neutral polymorphism throughout the genome. The pattern of reduction depends on the selective advantage and recurrence rate of the sweeps. Because many adaptive substitutions responsible for these sweeps also contribute to nonsynonymous divergence, the spatial distribution of nonsynonymous divergence also reflects the distribution of adaptive substitutions. Thus, the spatial correspondence between neutral polymorphism and nonsynonymous divergence may be especially informative about the process of adaptation. Here we study this correspondence using genomewide polymorphism data from Drosophila simulans and the divergence between D. simulans and D. melanogaster. Focusing on highly recombining portions of the autosomes, at a spatial scale appropriate to the study of selective sweeps, we find that neutral polymorphism is both lower and, as measured by a new statistic Q(S), less homogeneous where nonsynonymous divergence is higher and that the spatial structure of this correlation is best explained by the action of strong recurrent selective sweeps. We introduce a method to infer, from the spatial correspondence between polymorphism and divergence, the rate and selective strength of adaptation. Our results independently confirm a high rate of adaptive substitution (approximately 1/3000 generations) and newly suggest that many adaptations are of surprisingly great selective effect (approximately 1%), reducing the effective population size by approximately 15% even in highly recombining regions of the genome.
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