ArticleGenetics2007
Differential nuclear localization does not determine the silencing status of Saccharomyces cerevisiae telomeres.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Impact of Chromosome Fusions on 3D Genome Organization and Gene Expression in Budding Yeast.Genetics · 2020Article
- SUNny Ways: The Role of the SUN-Domain Protein Mps3 Bridging Yeast Nuclear Organization and Lipid Homeostasis.Frontiers in genetics · 2020Review
- Yeast epigenetics: the inheritance of histone modification states.Bioscience reports · 2019Review
- Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.PLoS genetics · 2016Article
- Finding a place in the SUN: telomere maintenance in a diverse nuclear landscape.Current opinion in cell biology · 2016Review
- One identity or more for telomeres?Frontiers in oncology · 2013Article
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization.Molecular biology of the cell · 2012Article
- Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.The EMBO journal · 2011Article
- The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.Nature cell biology · 2011Article
- Principles of chromosomal organization: lessons from yeast.The Journal of cell biology · 2011Review
- The budding yeast nucleus.Cold Spring Harbor perspectives in biology · 2010Review
- Chromosome arm length and nuclear constraints determine the dynamic relationship of yeast subtelomeres.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination.Genes & development · 2009Article
- The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion.Genome research · 2009Article
- yKu70/yKu80 and Rif1 regulate silencing differentially at telomeres in Candida glabrata.Eukaryotic cell · 2008Article
- Formalin can alter the intracellular localization of some transcription factors in Saccharomyces cerevisiae.FEMS yeast research · 2008Article
- Long-range chromosomal interactions and gene regulation.Molecular bioSystems · 2008Review
- Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres.Genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Saccharomyces cerevisiae, genes near telomeres are transcriptionally repressed, a phenomenon termed telomere position effect (TPE). Yeast telomeres cluster near the nuclear periphery, as do foci of proteins essential for TPE: Rap1p, Sir2-4p, and yKu70p/yKu80p. However, it is not clear if localization of telomeres to the periphery actually contributes to TPE. We examined the localization patterns of two telomeres with different levels of TPE: truncated VII-L and native VI-R. For both telomeres, localization to the nuclear periphery or to the silencing foci was neither necessary nor sufficient for TPE. Moreover, there was no correlation between TPE levels and the extent of localization. Tethering the truncated VII-L telomere to the nuclear periphery resulted in a modest increase in TPE. However, tethering did not bypass the roles of yKu70p, Sir4p, or Esc1p in TPE. Using mutations in RIF genes that bypass the role of Ku in TPE, a correlation between the level of silencing and the number of Rap1p foci present in the nucleus was observed, suggesting that Sir protein levels at telomeres determine both the level of TPE and the number of foci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.