Evidence map›Paper›PMID 18073312›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2008

Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity.

Jason J Winnick, W Michael Sherman, Diane L Habash, Michael B Stout, Mark L Failla, Martha A Belury, Dara P Schuster

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Aquatic Exercise on Brain Activity in Type 2 Diabetic: Randomized Clinical Trial.International journal of environmental research and public health · 2022
    Trial
  6. Trial
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  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Observational
  14. Review
  15. Review
  16. Review
  17. Article
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  19. Article
  20. Tailoring Exercise Prescription for Effective Diabetes Glucose Management.The Journal of clinical endocrinology and metabolism · 2025
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jason J WinnickSchool of Physical Activity and Educational Services, Department of Internal Medicine, The Ohio State University, Columbus 43210, USA. jason.winnick@vanderbilt.edu
W Michael Sherman
Diane L Habash
Michael B Stout
Mark L Failla
Martha A Belury
Dara P Schuster
The Ohio State University · US

Funding

YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI RAMMOHAN, KOTTIL WALAPPIL · 1985 to 2008
$22.7M
NCRR NIH HHS M01 RR000034NCRR NIH HHS M01RR00034
6 · The paper itself

Abstract

contextShort-term aerobic exercise training can improve whole-body insulin sensitivity in humans with type 2 diabetes mellitus; however, the contributions of peripheral and hepatic tissues to these improvements are not known.

objectiveOur objective was to determine the effect of 7-d aerobic exercise training on peripheral and hepatic insulin sensitivity during isoglycemic/hyperinsulinemic clamp conditions.

designSubjects were randomly assigned to one of two groups. The energy balance group consumed an isocaloric diet consisting of 50% carbohydrate, 30% fat, and 20% protein for 15 d. The energy balance plus exercise group consumed a similar diet over the 15 d and performed 50-min of treadmill walking at 70% of maximum oxygen consumption maximum during the second 7 d of the 15-d study period. Each subject underwent an initial isoglycemic/hyperinsulinemic clamp after 1-wk dietary control and a second clamp after completing the study.

settingThe study was performed at Ohio State University's General Clinical Research Center.

participantsThere were 18 obese, mildly diabetic humans included in the study.

interventionAerobic exercise training was performed for 7 d.

main outcome measuresWhole-body, peripheral, and hepatic insulin sensitivity were measured.

resultsExercise training did not have an impact on peripheral glucose uptake or endogenous glucose production during the basal state or low-dose insulin. Likewise, it did not alter endogenous glucose production during high-dose insulin. However, 1-wk of exercise training increased both whole-body (P<0.05) and peripheral insulin sensitivity (P<0.0001) during high-dose insulin.

conclusionImprovements to whole body insulin sensitivity after short-term aerobic exercise training are due to gains in peripheral, not heptic insulin sensitivity.

Indexed as

ExerciseInsulin ResistanceAdultBasal MetabolismDiabetes Mellitus, Type 2FemaleGlucoseGlucose Tolerance TestHumansLiverMaleMiddle AgedObesityOxygen ConsumptionGlucose

Identifiers

PMID18073312
PMCPMC2266960
OpenAlexW2154069424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.