ArticleNucleic acids research2007
Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Long-Patch Base Excision Repair of 5'-DNA-Peptide Cross-Links Derived from Abasic DNA Lesions.Biochemistry · 2026Article
- Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism.Antioxidants (Basel, Switzerland) · 2022Article
- Base and Nucleotide Excision Repair Pathways in DNA Plasmids Harboring Oxidatively Generated Guanine Lesions.Chemical research in toxicology · 2021Article
- The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion.DNA repair · 2020Article
- Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction.Nucleic acids research · 2020Article
- Remarkable Enhancement of Nucleotide Excision Repair of a Bulky Guanine Lesion in a Covalently Closed Circular DNA Plasmid Relative to the Same Linearized Plasmid.Biochemistry · 2020Article
- Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.Methods in enzymology · 2017Article
- Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions.Molecular biology of the cell · 2016Article
- TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.Nature communications · 2014Article
- A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.The Journal of biological chemistry · 2014Article
- Repair efficiency of (5'S)-8,5'-cyclo-2'-deoxyguanosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine depends on the complementary base.DNA repair · 2012Article
- Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood.Clinical genetics · 2012Article
- XPB, a subunit of TFIIH, is a target of the natural product triptolide.Nature chemical biology · 2011Article
- Initiation of DNA interstrand cross-link repair in mammalian cells.Environmental and molecular mutagenesis · 2010Review
- Similar nucleotide excision repair capacity in melanocytes and melanoma cells.Cancer research · 2010Article
- Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.Molecular cancer therapeutics · 2009Article
- Effect of cross-link structure on DNA interstrand cross-link repair synthesis.Chemical research in toxicology · 2009Article
- Circadian oscillation of nucleotide excision repair in mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection.Virology · 2008Article
- Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF.Nucleic acids research · 2008Article
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4 authors.
Funding
Abstract
The repair of DNA by nucleotide excision repair (NER) and non-homologous end joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Examination of NHEJ and NER in vitro using cell-free extracts has led to a deeper understanding of the biochemical mechanisms that underlie these processes. Current methods for production of whole-cell extracts (WCEs) to investigate NER and NHEJ start with one or more liters of culture containing 1-5 x 10(9) cells. Here, we describe a small-scale method for production of WCE that can be used to study NER. We also describe a rapid, small-scale method for the preparation of WCE that can be used in the study of NHEJ. These methods require less time, 20- to 1000-fold fewer cells than large-scale extracts, facilitate examination of numerous samples and are ideal for such applications as the study of host-virus interactions and analysis of mutant cell lines.
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