ArticleBrain research2008
Motor coordination deficits in mice lacking RGS9.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.Human brain mapping · 2024Article
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.bioRxiv : the preprint server for biology · 2023Article
- A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.PLoS biology · 2022Article
- Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.Pharmacological reviews · 2018Review
- The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.British journal of pharmacology · 2017Review
- Digoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury.The Journal of pharmacology and experimental therapeutics · 2016Article
- Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.PLoS genetics · 2015Article
- A microarray study of middle cerebral occlusion rat brain with acupuncture intervention.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia.Investigative ophthalmology & visual science · 2014Article
- Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Article
- The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
- The relationship between slow photoresponse recovery rate and temporal resolution of vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels.Molecular pharmacology · 2012Article
- Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.Journal of neurochemistry · 2012Article
- Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.The Journal of biological chemistry · 2012Article
- Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems.Psychopharmacology · 2012Article
- D(2)-Dopamine receptors target regulator of G protein signaling 9-2 to detergent-resistant membrane fractions.Journal of neurochemistry · 2012Article
- Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.Journal of neurochemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
RGS9-2 is a striatum-enriched protein that negatively modulates dopamine and opioid receptor signaling. We examined the role of RGS9-2 in modulating complex behavior. Genetic deletion of RGS9-2 does not lead to global impairments, but results in selective abnormalities in certain behavioral domains. RGS9 knockout (KO) mice have decreased motor coordination on the accelerating rotarod and deficits in working memory as measured in the delayed-match-to-place version of the water maze. In contrast, RGS9 KO mice exhibit normal locomotor activity, anxiety-like behavior, cue and contextual fear conditioning, startle threshold, and pre-pulse inhibition. These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.