ArticleMicrobial cell factories2007
Leptospirosis vaccines.
Article in Microbial cell factories, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Expression and Immunogenicity Analysis of Recombinant Leptospira Interrogans Surface Protein LigA in Mouse Model.Veterinary medicine and science · 2025Article
- Evaluating a Response to a Canine Leptospirosis Outbreak in Dogs Using an Owner Survey.Veterinary sciences · 2025Article
- Molecular Characterization of Gene Encoding Outer Membrane ProteinJournal of tropical medicine · 2024Article
- Current treatment options for leptospirosis: a mini-review.Frontiers in microbiology · 2024Review
- Bovine leptospirosis: effects on reproduction and an approach to research in Colombia.Tropical animal health and production · 2022Review
- Vaccination WithFrontiers in cellular and infection microbiology · 2022Article
- Severe leptospirosis in tropical Australia: Optimising intensive care unit management to reduce mortality.PLoS neglected tropical diseases · 2019Article
- An in silico approach towards identification of novel drug targets in pathogenic species of Leptospira.PloS one · 2019Article
- Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach.Scientific reports · 2018Article
- Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection.Scientific reports · 2018Article
- Advances & challenges in leptospiral vaccine development.The Indian journal of medical research · 2018Review
- Leptospirosis in the Caribbean: a literature review.Revista panamericana de salud publica = Pan American journal of public health · 2017Article
- Chimeric epitope vaccine against Leptospira interrogans infection and induced specific immunity in guinea pigs.BMC microbiology · 2016Article
- Future Challenges for Vaccinologists.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Comparative analysis of lipopolysaccharides of pathogenic and intermediately pathogenic Leptospira species.BMC microbiology · 2015Article
- Using discrete choice modeling to evaluate the preferences and willingness to pay for leptospirosis vaccine.Human vaccines & immunotherapeutics · 2015Article
- Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45.Human vaccines & immunotherapeutics · 2015Article
- Leptospirosis: the microscopic danger in paradise.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2014Review
- Vaccination with leptospiral outer membrane lipoprotein LipL32 reduces kidney invasion of Leptospira interrogans serovar canicola in hamsters.Clinical and vaccine immunology : CVI · 2014Article
- Production and characterization of a polyclonal antibody of anti-rLipL21-IgG against leptospira for early detection of acute leptospirosis.BioMed research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is a serious infection disease caused by pathogenic strains of the Leptospira spirochetes, which affects not only humans but also animals. It has long been expected to find an effective vaccine to prevent leptospirosis through immunization of high risk humans or animals. Although some leptospirosis vaccines have been obtained, the vaccination is relatively unsuccessful in clinical application despite decades of research and millions of dollars spent. In this review, the recent advancements of recombinant outer membrane protein (OMP) vaccines, lipopolysaccharide (LPS) vaccines, inactivated vaccines, attenuated vaccines and DNA vaccines against leptospirosis are reviewed. A comparison of these vaccines may lead to development of new potential methods to combat leptospirosis and facilitate the leptospirosis vaccine research. Moreover, a vaccine ontology database was built for the scientists working on the leptospirosis vaccines as a starting tool.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.