ArticleCNS drugs2008
National use of thrombolysis with alteplase for acute ischaemic stroke via telemedicine in Denmark: a model of budgetary impact and cost effectiveness.
Article in CNS drugs, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Cost-utility and cost-effectiveness studies of telemedicine, electronic, and mobile health systems in the literature: a systematic review.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2015Pooled it
- A systematic review of economic analyses of telehealth services using real time video communication.BMC health services research · 2010Pooled it
- The cost-effectiveness of telestroke in the treatment of acute ischemic stroke in China.Health economics review · 2026Article
- Perceptions, barriers, and facilitators of telemedicine adoption among physicians in Palestinian primary care: a cross-sectional study.BMC health services research · 2026Article
- Cost-utility tele-stroke in adults with acute ischemic stroke. A systematic review.Public health in practice (Oxford, England) · 2025Review
- Telemedicine for Stroke: Quantifying the Long-Term National Costs and Health Benefits.Frontiers in neurology · 2021Article
- Economic Evaluation Protocol and Statistical Analysis Plan for the Cost-Effectiveness of a Novel Australian Stroke Telemedicine Program; the Victorian Stroke Telemedicine (VST) program.Frontiers in neurology · 2020Article
- Telemedicine: A systematic review of economic evaluations.Medical journal of the Islamic Republic of Iran · 2017Review
- Teleneurology in stroke management: costs of service in different organizational models.Journal of neurology · 2014Article
- The history and future of telestroke.Nature reviews. Neurology · 2013Review
- Telemedicine or telephone consultation in patients with acute stroke.Current neurology and neuroscience reports · 2011Review
- Modeling stroke management: a qualitative review of cost-effectiveness analyses.The European journal of health economics : HEPAC : health economics in prevention and care · 2010Review
- An Empirical Analysis of the Current Need for Teleneuromedical Care in German Hospitals without Neurology Departments.International journal of telemedicine and applications · 2010Article
- Stroke telemedicine.Mayo Clinic proceedings · 2009Review
- Budget-impact analyses: a critical review of published studies.PharmacoEconomics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of this analysis was to assess the budgetary impact and cost effectiveness of the national use of thrombolysis with alteplase (recombinant tissue plasminogen activator; rt-PA) for acute ischaemic stroke via telemedicine in Denmark.
methodsComputations were based on a Danish health economic model of thrombolysis treatment of acute ischaemic stroke via telemedicine. Cost data for stroke units and satellite clinics were taken from the first practical experiences in Denmark with implementing thrombolysis via telemedical linkage to the Stroke Department at Aarhus University Hospital. Effectiveness data were taken from a published pooled analysis of results from randomized controlled trials of alteplase.
resultsThe calculations showed that the additional total costs to the hospitals of implementing thrombolysis with alteplase for acute ischaemic stroke via telemedicine were approximately $US3.0 (range 2.0-5.8) million per year in the case of five centres and five satellite clinics, or $US3.6 (range 2.4-7.0) million per year based on seven centres and seven satellite clinics. The incremental cost-effectiveness ratio was calculated to be approximately $US50,000 when taking a short time perspective (1 year), but thrombolysis was dominant (both cheaper and more effective) after as little as 2 years and cost effectiveness improved over longer time scales.
conclusionThe budgetary impact of using thrombolysis with alteplase for acute ischaemic stroke via telemedicine depends on the existing capacity and organizational conditions at the local hospitals. The health economic model computations suggest that the macroeconomic costs may balance with savings in care and rehabilitation after as little as 2 years, and that potentially large long-term savings are associated with thrombolysis with alteplase delivered by telemedicine, although the long-term calculations are uncertain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.