ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2007
Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization?
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Chemical Compatibility of N-Acetylcysteine After the Simultaneous Intravenous Administration of Ondansetron.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures.BMC medical informatics and decision making · 2023Article
- Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study.Current therapeutic research, clinical and experimental · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe sought to compare antiemetic use after acetaminophen poisoning in patients treated with oral or intravenous (IV) N-acetylcysteine (NAC).
methodsOur retrospective chart review identified 20 orally treated patients and 17 IV-treated patients. For both groups, we calculated the total number of antiemetic doses given, their associated cost, and also determined parameters that correlated with antiemetic use.
resultsIV-treated patients received fewer total antiemetic doses than those receiving oral NAC (1.1 0.2 vs. 2.8 0.7; P 0.04). Antiemetic cost correlated with doses received for both groups; however, because the regression lines differed (P 0.02), antiemetic therapy cost was less in IV-treated patients. In addition, serum acetaminophen concentration correlated with total antiemetic doses in oral NAC patients (P 0.002) but not with IV treatment patients (P 0.78).
conclusionsIntravenous NAC reduced antiemetic utilization, and it costs less than oral therapy. Furthermore, antiemetic use appeared to be determined by a combination of acetaminophen concentration and NAC administration route.
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