ReviewJournal of clinical immunology2008
Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis.
Review in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation.Journal of translational medicine · 2023Article
- T Lymphocyte Exhaustion During Human and Experimental Visceral Leishmaniasis.Frontiers in immunology · 2022Review
- Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines.Cytokine & growth factor reviews · 2013Review
- Transcriptional programming of the dendritic cell network.Nature reviews. Immunology · 2012Review
- CD8 T cell memory: it takes all kinds.Frontiers in immunology · 2012Article
- Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells.Frontiers in immunology · 2012Article
- How might infant and paediatric immune responses influence malaria vaccine efficacy?Parasite immunology · 2009Review
- Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B.Journal of virology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The body tends to maintain a relatively constant number of peripheral T cells, a phenomenon termed T cell homeostasis. Homeostasis is controlled by the coordinated activity of extrinsic regulation, most notably through cytokines of the common gamma chain (cgammaC) family and intrinsic regulation by transcription factors. Whereas the former mechanism has been extensively studied and is relatively well characterized, the transcription factors that govern the homeostasis of late-stage effector and memory T cells have been less well defined but include regulators such as T-bet, Eomes, Bcl6, and Id2. The transcriptional repressor, Blimp-1 is well known as a master regulator of the terminal differentiation of B cells into antibody secreting plasma cells. Recent experiments have now revealed that Blimp-1 is also a key regulator of T cell differentiation. Blimp-1 is expressed in differentiated effector T cells and controls their homeostasis. Interestingly, Blimp-1 expression is controlled by the same cgammaC cytokines that regulate T cell homeostasis suggesting a direct link between the extrinsic and intrinsic arms of the process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.