Evidence map›Paper›PMID 18071761›Full record

ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2008

Biomarkers for cancer cachexia: is there also a genetic component to cachexia?

B H L Tan, D A C Deans, R J E Skipworth, J A Ross, K C H Fearon

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Prevalence and Predictors of Malnutrition in Nasopharyngeal Carcinoma.Clinical medicine insights. Ear, nose and throat · 2015
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Treatment of cachexia in oncology.Indian journal of palliative care · 2010
    Article
  16. Article
  17. Article
  18. Cancer cachexia: medical management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010
    Review
  19. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

B H L TanClinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, Edinburgh, UK. benjamin.tan@ed.ac.uk
D A C Deans
R J E Skipworth
J A Ross
K C H Fearon
University of Edinburgh · GBEdinburgh Royal Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCancer cachexia is a severe debilitating disorder, which causes significant morbidity and mortality. In clinical practice, cachexia is often not treated until a late stage, when therapeutic options are limited.

objectiveIt is therefore of great interest to analyse early biomarkers of this syndrome.

conclusionIn this review article, we summarise recent biomarkers found in various body compartments. We also explore the likelihood of a genetic predisposition to cachexia and focus on the potential role of single nucleotide polymorphisms in genes coding for pro- and anti-inflammatory cytokines, and 'atrogenes' associated with wasting in skeletal muscle.

Indexed as

Biomarkers, TumorCachexiaGenetic Predisposition to DiseaseGenotypeHumansNeoplasmsBiomarkers, Tumor

Identifiers

PMID18071761
OpenAlexW1982804226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.