ReviewSeminars in immunopathology2008
Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria.
Review in Seminars in immunopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Functional evidence of hsa-miR-21-5p and hsa-miR-3158-3p in regulating immune pathways relevant to cerebral malaria.Molecular biology reports · 2026Article
- Monocyte dysregulation and systemic inflammation during pediatric falciparum malaria.JCI insight · 2017Article
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice.Parasitology research · 2016Article
- From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.Seminars in immunopathology · 2015Review
- Parasite virulence, co-infections and cytokine balance in malaria.Pathogens and global health · 2014Review
- Malarial pigment hemozoin and the innate inflammatory response.Frontiers in immunology · 2014Review
- Structure and dynamic behavior of Toll-like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols of Plasmodium falciparum.The FEBS journal · 2013Article
- The contribution of Plasmodium chabaudi to our understanding of malaria.Trends in parasitology · 2012Review
- Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Toll-like receptor signaling pathways--therapeutic opportunities.Mediators of inflammation · 2010Review
- The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.Journal of biomedicine & biotechnology · 2010Review
- Toll-like receptor initiated host defense against Toxoplasma gondii.Journal of biomedicine & biotechnology · 2010Review
- MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis.Infection and immunity · 2009Article
- CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Comparative genomics of Toll-like receptor signalling in five species.BMC genomics · 2009Article
- Identification of potential pathway mediation targets in Toll-like receptor signaling.PLoS computational biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are important to initiate the innate immune response to a wide variety of pathogens. The protective role of TLRs during infection with protozoan parasites has been established. In this regard, malaria represents an exception where activation of TLRs seems to be deleterious to the host. In this article, we review the recent findings indicating the contrasting role of Myeloid Differentiation Primary-Response gene 88 (MyD88) and TLRs during malaria and infection with other protozoa. These findings suggest that MyD88 may represent an Achilles' heel during Plasmodium infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.