ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Risk factors for decreased bone density and effects of HIV on bone in the elderly.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants.The Pediatric infectious disease journal · 2014Pooled it
- Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.PLoS medicine · 2012Trial
- Continuous antiretroviral therapy decreases bone mineral density.AIDS (London, England) · 2009Trial
- Bone Mineral Density in HIV-Infected People-the Experience of Craiova Regional Center.Biomedicines · 2025Article
- Prevalence and associated factors of low bone mineral density in people living with HIV: a cross-sectional study.Archives of osteoporosis · 2024Article
- Subtrochanteric Pathological Femur Fracture in an HIV-Positive Patient on Tenofovir-based antiretroviral therapy: A Case Report and Review of the Literature.Journal of orthopaedic case reports · 2023Article
- Human Immunodeficiency Virus (HIV) and Menopause Are Independently Associated With Lower Bone Mineral Density: Results From the Women's Interagency HIV Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- IL-27 Modulates the Cytokine Secretion in the T Cell-Osteoclast Crosstalk During HIV Infection.Frontiers in immunology · 2022Article
- Article
- Validation of a six-item dietary calcium screening tool among HIV patients in China.Public health nutrition · 2021Article
- Atypical femoral neck stress fracture in a human immunodeficiency virus-infected patient despite anti-osteoporotic treatment: A case report.Turkish journal of physical medicine and rehabilitation · 2020Article
- Influence of HIV Infection and Antiretroviral Therapy on Bone Homeostasis.Frontiers in endocrinology · 2020Review
- Substance Use Among Older People Living With HIV: Challenges for Health Care Providers.Frontiers in public health · 2019Review
- Low bone mineral density among HIV-infected patients in Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Article
- Bone mineral density in people living with HIV: a narrative review of the literature.AIDS research and therapy · 2017Review
- Alveolar bone in human immunodeficiency virus infection: is it changed by long-term antiretroviral therapy?International dental journal · 2017Article
- HIV Infection and Bone Abnormalities.The open orthopaedics journal · 2017Article
- In Utero Tenofovir Exposure Is not Associated With Fetal Long Bone Growth.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Article
- Perspectives on menopause and women with HIV.International journal of women's health · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledMost studies of bone density in HIV-infected individuals focus on young men. This study compares differences in bone density in elderly HIV positive men and women to HIV negative controls. Bone density was lower in the lumbar spine and hip in the HIV-infected group. Antiretrovirals may be associated with decreased bone mineralization.
introductionIndividuals with human immunodeficiency virus (HIV) may be at increased risk for osteoporosis. Prolonged exposures to HIV and/or antiretroviral therapy are possible causes for this association. This study compares differences in bone mineral density (BMD) in elderly HIV positive men and women to HIV negative controls.
methodsA cross-sectional study was conducted among 57 HIV-infected and 47 HIV negative subjects over age 55. BMD at the lumbar spine and total hip and markers of bone turnover were compared.
resultsBMD was borderline lower in the lumbar spine and significantly lower in the hip in the HIV-infected group. Controlling for age, sex, race and body mass index, differences between the groups were significant at both sites. There was no difference in markers of bone turnover between the groups. Tenofovir use was significantly associated with decreased BMD at the spine while protease inhibitor use was significantly associated with decreased BMD at the hip.
conclusionElderly men and women with HIV have lower bone mass than HIV negative controls. Decreased body mass index was the most important risk factor associated with decreased BMD. Bone demineralization was observed among HIV-infected subjects receiving either tenofovir or a protease inhibitor.
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