ArticleJournal of human genetics2008
Trends in meta-analysis of genetic association studies.
Article in Journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis.Renal failure · 2018Pooled it
- Obstructive Sleep Apnea Susceptibility Genes in Chinese Population: A Field Synopsis and Meta-Analysis of Genetic Association Studies.PloS one · 2015Pooled it
- MTHFR gene polymorphism and risk of myeloid leukemia: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Pooled it
- Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies.Molecular psychiatry · 2013Pooled it
- The role of MTHFR gene in multiple myeloma.Journal of human genetics · 2008Pooled it
- Risk Factor Genes in Patients with Dystonia: A Comprehensive Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Review
- Association ofBiomedical reports · 2014Article
- Article
- Plasma homocysteine and genetic variants of homocysteine metabolism enzymes in patients from central Greece with primary open-angle glaucoma and pseudoexfoliation glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- Lack of association between the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphism and the risk of benign prostatic hyperplasia in Caucasian men.Molecular biology reports · 2013Article
- Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction.Journal of translational medicine · 2013Article
- Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study.Molecular biology reports · 2013Article
- HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.American journal of human genetics · 2012Article
- Comprehensive literature review and statistical considerations for GWAS meta-analysis.Nucleic acids research · 2012Review
- Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index.BMC medical research methodology · 2011Article
- Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study.BMC pregnancy and childbirth · 2011Article
- GATES: a rapid and powerful gene-based association test using extended Simes procedure.American journal of human genetics · 2011Article
- Recent human evolution has shaped geographical differences in susceptibility to disease.BMC genomics · 2011Article
- Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of published genetic association studies (GASs) is increasing tremendously due to the availability of mapped single-nucleotide polymorphisms (SNPs) and advances in genotyping technologies. A search in HuGENet illustrates the rapid accumulation of evidence for major diseases. Recently, there has been a lot of activity regarding genome-wide association studies (GWASs), and a growing number of forthcoming studies is expected. GASs and GWASs are usually underpowered to detect significant associations, and the varying quality of reporting publications befuddles researchers. A meta-analysis can increase power and provide standards of reporting results. However, the conduct of a meta-analysis of GASs faces a major obstacle, which is the structure and diversity of stored information in databases. Similar problems are expected for GWASs, though the data are not yet publicly available. The development of a Web-based system for the detailed and structured recording of GAS or GWAS data, accompanied by an estimation of the overall genetic risk effects, would enable scientists to keep track of evidence for gene-disease associations.
Indexed as
Identifiers
18071627What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.