ArticleInternational journal of biological sciences2007
Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.
Article in International journal of biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Role of NELF-B in supporting epithelial-mesenchymal transition and cell proliferation during hepatocellular carcinoma progression.Oncology letters · 2021Article
- Estrogen receptor alpha (ERα)-mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2).Cell biology and toxicology · 2020Article
- BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression.Cancers · 2018Review
- Transcription pausing regulates mouse embryonic stem cell differentiation.Stem cell research · 2017Article
- Article
- A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.The Journal of biological chemistry · 2013Article
- Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.Neoplasia (New York, N.Y.) · 2013Article
- Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites.PloS one · 2013Article
- BRCA1 and microRNAs: emerging networks and potential therapeutic targets.Molecules and cells · 2012Review
- Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.Nature medicine · 2011Article
- Article
- Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae.Cell cycle (Georgetown, Tex.) · 2008Article
- Hereditary breast cancer: new genetic developments, new therapeutic avenues.Human genetics · 2008Review
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBRA1 modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells. Its expression is significantly reduced in metastatic and recurrent breast cancer, pointing to a tumor suppressor function in breast cancer development. In light of these initial implications of COBRA1 in human breast cancer, the current investigation sought to obtain more direct functional evidence that links COBRA1 with BRCA1 in transcriptional regulation in breast cancer cells. Small hairpin RNA (shRNA)-mediated gene knockdown and gene expression microarray were used to study the impact of COBRA1 and BRCA1 on global transcription in the same breast cancer cell background. The gene expression profiling study in tissue culture cells uncovers a significant overlap of COBRA1- and BRCA1-regulated genes, many of which have been previously implicated in breast cancer progression. The data shown herein support the notion that COBRA1 and BRCA1 may engage in common gene regulatory pathways to suppress breast cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.