ArticleAntimicrobial agents and chemotherapy2008
Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Molecular Characterization of Fluoroquinolone-ResistantPathogens (Basel, Switzerland) · 2021Article
- Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.PLoS neglected tropical diseases · 2016Article
- DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae.PLoS neglected tropical diseases · 2016Article
- Resistance of M. leprae to quinolones: a question of relativity?PLoS neglected tropical diseases · 2013Article
- Amino acid substitutions at position 95 in GyrA can add fluoroquinolone resistance to Mycobacterium leprae.Antimicrobial agents and chemotherapy · 2012Article
- Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance.PLoS neglected tropical diseases · 2012Article
- Detection of antibiotic resistance in leprosy using GenoType LepraeDR, a novel ready-to-use molecular test.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.
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