ArticleInfection and immunity2008
Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- The Role of Macrophages in the Immune Response to Peritoneal Infection withPathogens (Basel, Switzerland) · 2026Article
- Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis.World journal of gastroenterology · 2026Article
- Association of visceral obesity with Helicobacter pylori seropositivity and mortality in US adults.BMC infectious diseases · 2026Article
- Endogenous glucocorticoids are required for normal macrophage activation and gastricAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Animal Models andJournal of clinical medicine · 2022Review
- Insect tea attenuates hydrochloric acid and ethanol-induced mice acute gastric injury.Experimental and therapeutic medicine · 2017Article
- CagA promotes proliferation and inhibits apoptosis of GES-1 cells by upregulating TRAF1/4-1BB.Molecular medicine reports · 2017Article
- A possible role of GDDR in the development of Helicobacter pylori-associated gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Are gastric mucosal macrophages responsible for gastric injury in acute pancreatitis?World journal of gastroenterology · 2015Article
- Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis.BioMed research international · 2015Review
- TLR9 and NF-κB are partially involved in activation of human neutrophils by Helicobacter pylori and its purified DNA.PloS one · 2014Article
- Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.Infection and immunity · 2012Article
- Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.Molecular vision · 2012Article
- Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression.Gastroenterology · 2010Article
- Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients.World journal of gastroenterology · 2009Article
- Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.Journal of gastroenterology · 2009Article
- Inflammation and cancer: role of nuclear factor-kappaB activation.Cancer science · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mongolian gerbil model of Helicobacter pylori infection resembles human gastritis. In this study, we investigated the role of NF-kappaB activation in H. pylori-infected gerbils. Activated macrophages were significantly increased in H. pylori-infected gastric mucosa and were identified as being important cells with potent activation of NF-kappaB, which plays an important part in producing proinflammatory cytokines. Macrophage depletion by the administration of clodronate resulted in milder inflammation in gerbils infected with H. pylori. In macrophages, the inhibition of IkappaB kinase beta (IKKbeta), which is a critical kinase for NF-kappaB activation, resulted in lower proinflammatory cytokine expression caused by heat-killed H. pylori cells. Furthermore, treatment with IKKbeta inhibitor resulted in milder inflammation in gerbils with H. pylori gastritis. Collectively, our data suggest that H. pylori-mediated gastric inflammation critically depends on the efficient recruitment and activation of macrophages, with sufficient NF-kappaB activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.