ArticleClinical and experimental immunology2008
High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The relation of circulating YKL-40 to levels and decline of lung function in adult life.Respiratory medicine · 2013Pooled it
- Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panel.medRxiv : the preprint server for health sciences · 2024Article
- Frailty is related to serum inflammageing markers: results from the VITAL study.Immunity & ageing : I & A · 2023Article
- Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.JCI insight · 2021Article
- Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach.Scientific reports · 2021Article
- Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis.International journal of molecular sciences · 2021Article
- Neutrophils as a Potential Source of Chitinase-3-like Protein 1 in Cystic Fibrosis.Inflammation · 2018Article
- Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction.Cardiology research and practice · 2018Article
- Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival.World journal of gastroenterology · 2017Article
- Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease.International journal of molecular sciences · 2014Article
- Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke.PloS one · 2012Article
- Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects.Arthritis research & therapy · 2011Article
- Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.Annual review of physiology · 2011Review
- Age-related alterations in retinal neurovascular and inflammatory transcripts.Molecular vision · 2011Article
- Utility of Serum YKL-40 as a Tumor-Specific Marker of Hepatobiliary Malignancies.Gut and liver · 2010Article
- YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?Cancers · 2010Article
- Mycoses in the elderly.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Review
- Role of breast regression protein-39/YKL-40 in asthma and allergic responses.Allergy, asthma & immunology research · 2010Article
- Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.Mechanisms of ageing and development · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
YKL-40 is secreted by macrophages, neutrophils, chondrocytes, endothelial-, vascular smooth muscle- and cancer cells. Interleukin (IL)-6 stimulates YKL-40 production in human in vivo studies. High serum YKL-40 is associated with poor prognosis in patients with inflammatory diseases and cancer. We studied whether serum YKL-40 was associated with systemic low-level inflammation, an immune risk phenotype, and mortality in relatively healthy 80-year old humans. Serum YKL-40, IL-6 and tumour necrosis factor (TNF)-alpha were measured by enzyme-linked immunosorbent assays (ELISAs) in octogenarians (n = 151) and serum YKL-40 in 18-30-year-olds (n = 89). Fifty-one of the octogenarians died during the 6-year follow-up. Serum YKL-40 in octogenarians was higher compared to the level in young people (median 116 versus 31 microg/l, P < 0.0005). Serum YKL-40 correlated with serum IL-6 in elderly women (Spearman's rho = 0.30, P = 0.009) and men (rho = 0.25, P = 0.003), but only with serum TNF-alpha (rho = 0.23, P = 0.05) and C-reactive protein (CRP) (rho = 0.57, P < 0.0005) among the elderly women. In addition, high serum level of YKL-40 was associated with a low CD4 : CD8 cell ratio. Univariate analysis of serum YKL-40 (logarithmically transformed and divided by tertiles) showed significant association with all-cause mortality [tertile 3: hazard ratio (HR) = 2.38, 95% confidence interval (CI): 1.19-4.78, P = 0.02]. The effect persisted after adjusting for potential confounders (sex, smoking, body mass index, chronic disease and anti-inflammatory medicine). These results suggest that serum YKL-40 is a prognostic and sensitive biomarker of all-cause mortality in octogenarians.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.