ArticlePLoS genetics2007
A mechanism misregulating p27 in tumors discovered in a functional genomic screen.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Protein Quantification and Imaging by Surface-Enhanced Raman Spectroscopy and Similarity Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Molecular signatures for CCN1, p21 and p27 in progressive mantle cell lymphoma.Journal of cell communication and signaling · 2019Article
- Suppression of AURKA alleviates p27 inhibition on Bax cleavage and induces more intensive apoptosis in gastric cancer.Cell death & disease · 2018Article
- The miR-106a~363Oncotarget · 2017Article
- Rp58 and p27Neural development · 2017Article
- Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy.Oncotarget · 2014Article
- Article
- Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B.Cancer medicine · 2012Article
- p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.The Journal of clinical investigation · 2012Article
- Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.The Journal of clinical investigation · 2011Article
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- Clinical relevance of SKP2 alterations in metastatic melanoma.Pigment cell & melanoma research · 2011Article
- Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis.Carcinogenesis · 2009Article
- High-throughput insertional mutagenesis screens in mice to identify oncogenic networks.Nature reviews. Cancer · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The cyclin-dependent kinase inhibitor p27(KIP1) is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is rarely mutated in tumors. Therefore misregulation of p27, rather than loss of the gene, is responsible for tumor-associated decreases in p27 protein levels. We performed a functional genomic screen in p27(+/-) mice to identify genes that regulate p27 during lymphomagenesis. This study demonstrated that decreased p27 expression in tumors resulted from altered transcription of the p27 gene, and the retroviral tagging strategy enabled us to pinpoint relevant transcription factors. inhibitor of DNA binding 3 (Id3) was isolated and validated as a transcriptional repressor of p27. We further demonstrated that p27 was a downstream target of Id3 in src-family kinase Lck-driven thymic lymphomagenesis and that p27 was an essential regulator of Lck-dependent thymic maturation during normal T-cell development. Thus, we have identified and characterized transcriptional repression of p27 by Id3 as a new mechanism decreasing p27 protein in tumors.
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Registered trials
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