Trial reportWorld journal of gastroenterology2007
Relationship between vascular invasion and microvessel density and micrometastasis.
Trial report in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of venous resection in pancreatoduodectomy: A systematic review and meta-analysis.Medicine · 2021Pooled it
- Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging.Journal of Zhejiang University. Science. B · 2024Article
- Molecular Imaging for Lung Cancer: Exploring Small Molecules, Peptides, and Beyond in Radiolabeled Diagnostics.Pharmaceutics · 2024Review
- Mono+ algorithm assessment of the diagnostic value of dual-energy CT for high-risk factors for colorectal cancer: a preliminary study.Quantitative imaging in medicine and surgery · 2024Article
- Tissue Microvessel Density as a Potential Predictive Marker for Vascular Invasion in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Vessel size as a marker of survival in estrogen receptor positive breast cancer.Breast cancer research and treatment · 2023Article
- The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression.Current issues in molecular biology · 2022Article
- Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer.Oncogene · 2018Review
- Anti-proliferative and angio-suppressive effect of Stoechospermum marginatum (C. Agardh) Kutzing extract using various experimental models.Nutrition research and practice · 2014Article
- Diabetes, body mass index, and outcomes in hepatocellular carcinoma patients undergoing liver transplantation.Transplantation · 2012Article
- Obesity and microvascular invasion in hepatocellular carcinoma.Cancer investigation · 2010Article
- Study on relationship between angiogenesis and micrometastases of peripheral blood in breast cancer.Journal of cancer research and clinical oncology · 2009Article
- Prognostic value of microvascular density in dukes a and B (t1-t4, n0, m0) colorectal carcinomas.Gastroenterology research and practice · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the relationship between vascular invasion and microvessel density (MVD) of tissue and micrometastasis in blood.
methodsVascular invasion was detected by both hematoxylin and eosin staining and immunohistochemiscal staining. Blood samples were collected from 17 patients with vascular invasion and 29 patients without vascular invasion and examined for cytokeratin20 (CK20) expression by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Microvessel density of tissue samples was also determined by immunohistochemistry using antibodies to CD105.
resultsCK20 was detected in 12 of the 17 patients with vascular invasion and in 9 of the 29 patients without vascular invasion. Positive RT-PCR was significantly correlated with vascular invasion (70.6% vs 30.0%, P < 0.05). The average MVD was significantly higher in patients with positive vascular invasion than in patients with negative vascular invasion (29.2 +/- 3.3 vs 25.4 +/- 4.7, P < 0.05). The vascular invasion detected with hematoxylin-eosin staining was less than that with immunohistochemical staining. There was a significant difference between the two staining methods (19.6% vs 36.9%, P < 0.05).
conclusionPositive CK20 RT-PCR, depth of tumor invasion, lymph node status, metastasis and MVD are significantly correlated with vascular invasion. Immunohistochemical staining is more sensitive than hematoxylin-eosin staining for detecting vascular invasion.
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