ArticleWorld journal of gastroenterology2007
Relationship between survivin expression and recurrence, and prognosis in hepatocellular carcinoma.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Meta-analysis: prognostic value of survivin in patients with hepatocellular carcinoma.PloS one · 2013Pooled it
- Therapeutic Efficacy of YM155 to Regulate an Epigenetic Enzyme in Major Subtypes of RCC.International journal of molecular sciences · 2023Article
- Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma.International journal of molecular sciences · 2018Review
- From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma.PeerJ · 2017Article
- Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β.Cell cycle (Georgetown, Tex.) · 2016Article
- Survivin as a preferential target for cancer therapy.International journal of molecular sciences · 2014Review
- Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.Cell death & disease · 2013Article
- Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases.Viruses · 2012Review
- A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase.Cancers · 2012Article
- Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma.World journal of gastroenterology · 2011Article
- Survivin as an immunotherapeutic target for adult and pediatric malignant brain tumors.Cancer immunology, immunotherapy : CII · 2010Review
- Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.BMC cancer · 2009Article
- Dysregulation of apoptosis in hepatocellular carcinoma cells.World journal of gastroenterology · 2009Review
- Increased survivin expression confers chemoresistance to tumor-associated endothelial cells.The American journal of pathology · 2008Article
- Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma.Biomedical imaging and intervention journalArticle
- Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the expression of the inhibitor of apoptosis protein survivin in hepatocellular carcinoma (HCC), and its correlation with clinicopathological factors, cell proliferation, recurrence and prognosis after hepatectomy.
methodsImmunohistochemical staining of survivin and Ki-67 was performed by the standard streptavidin-peroxidase technique on paraffin sections of 55 cases of HCC.
resultsThe positive rate of survivin in HCC was 52.7% (29/55). Significant correlation was found between survivin expression with portal vein thrombi and intrahepatic matastasistic nodes (P < 0.05). The recurrent rate in survivin-positive HCC was significantly higher than that in survivin-negative HCC after hepatectomy, the 1- and 3-year survival rate in patients with survivin-positive tumors was significantly lower than that in patients with survivin-negative tumors (58.62 and 10.34% vs 76.92 and 30.77%, P < 0.05, log-rank test). The proliferation index (Ki-67) in survivin-positive HCC (33.83% +/- 18.90%) was significantly higher than that in survivin-negative HCC (19.60% +/- 19.35%) (P < 0.05).
conclusionSurvivin may play an important role in progression of HCC by promoting cell proliferation, and may be positively correlated with high risk of disease recurrence and poor prognosis in HCC. Its expression may serve as a prognostic factor for patients with HCC after hepatectomy.
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