ArticleDevelopmental biology2008
Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 173 citations in OpenAlex.
- Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance.Developmental biology · 2025Article
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- Germline proliferation trades off with lipid metabolism inEvolution letters · 2024Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
- Insulin signaling in development.Development (Cambridge, England) · 2023Article
- Article
- Single-cell RNA sequencing identifies eggplant as a regulator of germ cell development in Drosophila.EMBO reports · 2023Article
- Genetic and Epigenetic Regulation ofJournal of developmental biology · 2023Review
- Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.Cell reports · 2022Article
- A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis.Developmental cell · 2022Article
- Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division.Development (Cambridge, England) · 2021Article
- Characterization of histone inheritance patterns in the Drosophila female germline.EMBO reports · 2021Article
- Review
- Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size.G3 (Bethesda, Md.) · 2021Article
- Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps ofDevelopment (Cambridge, England) · 2021Article
- Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.Genetics · 2021Article
- Article
- Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit FlyFrontiers in physiology · 2021Review
- Germline Stem and Progenitor Cell Aging inFrontiers in cell and developmental biology · 2021Review
- Direct Imaging of Lipid Metabolic Changes inFrontiers in aging · 2021Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The external environment influences stem cells, but this process is poorly understood. Our previous work showed that germline stem cells (GSCs) respond to diet via neural insulin-like peptides (DILPs) that act directly on the germ line to upregulate stem cell division and cyst growth under a protein-rich diet in Drosophila. Here, we report that DILPs specifically control the G2 phase of the GSC cell cycle via phosphoinositide-3 kinase (PI3K) and dFOXO, and that a separate diet mediator regulates the G1 phase. Furthermore, GSC tumors, which escape the normal stem cell regulatory microenvironment, or niche, still respond to diet via both mechanisms, indicating that niche signals are not required for GSCs to sense or respond to diet. Our results document the effects of diet and insulin-like signals on the cell cycle of stem cells within an intact organism and demonstrate that the response to diet requires multiple signals. Moreover, the retained ability of GSC tumors to respond to diet parallels the long known connections between diet, insulin signaling, and cancer risk in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.