ArticleVirus research2008
The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus.
Article in Virus research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88 citing papers in PubMed.
- Evasion of humoral immune responses by a key mutational region of the S2 subunit in PEDV variants.mBio · 2026Article
- ZNF219 inhibits porcine epidemic diarrhea virus by degrading viral S2 protein.Virologica Sinica · 2026Article
- Reclassification and Recombination Analysis of Porcine Epidemic Diarrhea Virus Strains in South Korea Based on Spike Gene Analysis.Veterinary sciences · 2026Article
- Isolation and assessment of characterization of porcine epidemic diarrhea virus GD1 strain from China.Frontiers in veterinary science · 2026Article
- How Does Porcine Epidemic Diarrhea Virus Escape Host Innate Immunity?Pathogens (Basel, Switzerland) · 2025Review
- Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development.Frontiers in immunology · 2025Article
- Neutralizing VHH Antibodies Targeting the Spike Protein of PEDV.Veterinary sciences · 2024Article
- Article
- Quercetin inhibition of porcine intestinal alpha coronavirus in vitro and in vivo.BMC veterinary research · 2024Article
- Porcine Epidemic Diarrhea Virus: Etiology, Epidemiology, Antigenicity, and Control Strategies in China.Animals : an open access journal from MDPI · 2024Review
- Research progress of porcine epidemic diarrhea virus S protein.Frontiers in microbiology · 2024Review
- Spike 1 trimer, a nanoparticle vaccine against porcine epidemic diarrhea virus induces protective immunity challenge in piglets.Frontiers in microbiology · 2024Article
- Molecular Characterization of Porcine Epidemic Diarrhea Virus from Field Samples in South Korea.Viruses · 2023Article
- Spike Gene Analysis and Prevalence of Porcine Epidemic Diarrhea Virus from Pigs in South Korea: 2013-2022.Viruses · 2023Article
- Correlation between the IgG/IgA Antibody Response against PEDV Structural Protein and Virus Neutralization.Microbiology spectrum · 2023Article
- Epidemiological and genetic characterization of porcine epidemic diarrhea virus in the Mekong Delta, Vietnam, from 2015 to 2017.Archives of virology · 2023Article
- Isolation and characterization of porcine epidemic diarrhea virus with a novel continuous mutation in the S1Frontiers in microbiology · 2023Article
- Construction and immunogenicity of a trypsin-independent porcine epidemic diarrhea virus variant.Frontiers in immunology · 2023Article
- Virus-like particle vaccines with epitopes from porcine epidemic virus and transmissible gastroenteritis virus incorporated into self-assembling ADDomer platform provide clinical immune responses in piglets.Frontiers in immunology · 2023Article
- A Porcine Epidemic Diarrhea Virus Isolated from a Sow Farm Vaccinated with CV777 Strain in Yinchuan, China: Characterization, Antigenicity, and Pathogenicity.Transboundary and emerging diseases · 2023Article
28 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
The spike protein of Porcine epidemic diarrhea virus is the main surface glycoprotein involved in virus attachment and entry and therefore is the target of neutralizing antibodies. Here, the immunogenicity of a novel antigenic domain found on the carboxy-terminal of the spike protein characterized by the peptide motif GPRLQPY, was evaluated. A synthetic peptide whose linear sequence is identical to the 24a.a. carboxy-terminal portion of the spike protein (S-CT24) elicited a strong antibody response in BALB/c mice that had specific reactivity against the S-CT24 and PEDV. These antibodies were shown to have a specific affinity to the GPRLQPY motif, as demonstrated by non-reactivity with a peptide that lacks this motif. In addition, antiS-CT24 antibodies exhibited neutralizing activities against KPEDV-9 in focus reduction neutralization tests suggesting that the GPRLQPY motif induces neutralizing antibodies against PEDV.
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