ArticleNeuroscience research2008
Analysis of daily and circadian gene expression in the rat pineal gland.
Article in Neuroscience research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the Effects of Blue Light on Circadian Rhythm in SD Rat.Nature and science of sleep · 2026Article
- Rhythmic Diurnal Synthesis and Signaling of Retinoic Acid in the Rat Pineal Gland and Its Action to Rapidly Downregulate ERK Phosphorylation.Molecular neurobiology · 2018Article
- Circadian Plasticity in the Brain of Insects and Rodents.Frontiers in neural circuits · 2018Review
- Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin.Cellular signalling · 2015Article
- Noradrenaline upregulates T-type calcium channels in rat pinealocytes.The Journal of physiology · 2015Article
- Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome.PloS one · 2015Article
- Extracellular low pH affects circadian rhythm expression in human primary fibroblasts.Biochemical and biophysical research communications · 2011Article
- Pineal function: impact of microarray analysis.Molecular and cellular endocrinology · 2010Review
- Pharmacological modulators of the circadian clock as potential therapeutic drugs.Mutation research · 2009Article
- Transcriptome analysis of the zebrafish pineal gland.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.The Journal of biological chemistry · 2009Article
- Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina.Experimental eye research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian pineal gland is an important component of the circadian system. In the present study, we examined the expression of roughly 8000 genes in the rat pineal gland as a function of time of day under light-dark (LD) cycles and in constant dark (DD) using oligo DNA microarray technique. We identified 47 and 13 genes that showed higher levels at night and day, respectively, under LD. The same patterns of expression were also observed in DD. About half of the genes that peaked at night have a known biological function, i.e., transcription factors and proteins that are involved in signaling cascades, whereas 14 are expressed sequence tags and 8 have an unknown biological function. Twelve of the genes that were up-regulated at night were also up-regulated after 1h NE stimulation, thus suggesting that the expression of these genes is controlled by adrenergic mechanisms. Of the 13 genes that were up-regulated in the daytime, 6 coded for proteins that are involved in intracellular signaling pathways. The results obtained with microarray analysis were well correlated with data obtained using real time quantitative RT-PCR. The present results provide new materials to dissect and understand the pineal physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.