Trial reportBMC musculoskeletal disorders2007
The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial.
Trial report in BMC musculoskeletal disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Laser Therapy on Chronic Knee Joint Osteoarthritis Patients
Effects of Strength and Balance Training to Reduce the Fall Risk in Knee Osteoarthritis Patients
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Pooled it
- Progressive resistance strength training for improving physical function in older adults.The Cochrane database of systematic reviews · 2009Pooled it
- Effect of low-level laser therapy (904 nm) and static stretching in patients with knee osteoarthritis: a protocol of randomised controlled trial.BMC musculoskeletal disorders · 2015Trial
- Altered knee joint loading in patients with chronic ankle instability during running.BMC sports science, medicine & rehabilitation · 2026Article
- Addition of immersive virtual reality-mediated programs with conventional physiotherapy on quality of life in knee osteoarthritis - A protocol of a randomized controlled trial.Journal of education and health promotion · 2026Article
- Varus deformity in medial knee osteoarthritis correlates with fatty degeneration of lower limb muscles: Artificial intelligence-based computed tomography analysis.Journal of experimental orthopaedics · 2025Article
- Effect of Lateral Wedge Insole With and Without Thigh and Abdominal Muscle Strengthening Exercises on the Balance of Young People With Genuvarum: A Randomize Controlled Trial.Health science reports · 2025Article
- Economic burden of knee joint replacement in Iran.Cost effectiveness and resource allocation : C/E · 2024Article
- Impacts of asymmetric hip rotation angle on gait biomechanics in patients with knee osteoarthritis.Knee surgery & related research · 2024Article
- Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.BMJ open · 2024Article
- Exploring the potential of the sit-to-stand test for self-assessment of physical condition in advanced knee osteoarthritis patients using computer vision.Frontiers in public health · 2024Article
- Effect of adding hip exercises to general rehabilitation treatment of knee osteoarthritis on patients' physical functions: a randomized clinical trial.BMC sports science, medicine & rehabilitation · 2023Article
- Can marathon running improve knee damage of middle-aged adults? A prospective cohort study.BMJ open sport & exercise medicine · 2019Article
- Carryover effect of hip and knee exercises program on functional performance in individuals with patellofemoral pain syndrome.Journal of physical therapy science · 2017Article
- Relationship between trunk function evaluated using the trunk righting test and physical function in patients with knee osteoarthritis.Journal of physical therapy science · 2017Article
- Treatment of knee osteoarthritis in relation to hamstring and quadriceps strength.Journal of physical therapy science · 2013Article
- A regional interdependence model of musculoskeletal dysfunction: research, mechanisms, and clinical implications.The Journal of manual & manipulative therapy · 2013Review
- Article
- Effects of progressive resistance strength training on knee biomechanics during single leg step-up in persons with mild knee osteoarthritis.Clinical biomechanics (Bristol, Avon) · 2011Article
- A narrative review of the published chiropractic literature regarding older patients from 2001-2010.The Journal of the Canadian Chiropractic Association · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower limb strengthening exercises are an important component of the treatment for knee osteoarthritis (OA). Strengthening the hip abductor and adductor muscles may influence joint loading and/or OA-related symptoms, but no study has evaluated these hypotheses directly. The aim of this randomised, single-blind controlled trial is to determine whether hip abductor and adductor muscle strengthening can reduce knee load and improve pain and physical function in people with medial compartment knee OA. METHODS/
design88 participants with painful, radiographically confirmed medial compartment knee OA and varus alignment will be recruited from the community and randomly allocated to a hip strengthening or control group using concealed allocation stratified by disease severity. The hip strengthening group will perform 6 exercises to strengthen the hip abductor and adductor muscles at home 5 times per week for 12 weeks. They will consult with a physiotherapist on 7 occasions to be taught the exercises and progress exercise resistance. The control group will be requested to continue with their usual care. Blinded follow up assessment will be conducted at 12 weeks after randomisation. The primary outcome measure is the change in the peak external knee adduction moment measured during walking. Questionnaires will assess changes in pain and physical function as well as overall perceived rating of change. An intention-to-treat analysis will be performed using linear regression modelling and adjusting for baseline outcome values and other demographic characteristics. DISCUSSION: Results from this trial will contribute to the evidence regarding the effect of hip strengthening on knee loads and symptoms in people with medial compartment knee OA. If shown to reduce the knee adduction moment, hip strengthening has the potential to slow disease progression.
trial registrationAustralia New Zealand Clinical Trials Registry ACTR12607000001493.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.